Document Detail

Is colonic fermentation minimized by increasing meal frequency?
MedLine Citation:
PMID:  1879386     Owner:  NLM     Status:  MEDLINE    
It has been suggested that, although increasing meal frequency has metabolic advantages in terms of carbohydrate and lipid metabolism, the efficiency of small intestinal absorption may be enhanced, thus reducing the extent of colonic fermentation. Since this may be undesirable, we have tested whether increasing meal frequency reduces the amount of carbohydrate fermented into the colon. Accordingly, seven healthy male volunteers took, in random order, two identical 2-week metabolic diets divided into either seventeen or three meals daily. On day 13 of each period measurements were made throughout the day of breath H2 and serum acetate, as markers of colonic fermentation. Mean levels of both breath H2 and acetate were similar on both diets, being lower on nibbling by 3.2 +/- 0.8 ppm and 25 +/- 9 mumols/l respectively (not significant). This study failed to demonstrate an effect of more efficient carbohydrate absorption with increased meal frequency.
F Brighenti; S Ciappellano; V Vuksan; A V Rao; T M Wolever; A Jenkins; D J Jenkins; G Testolin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  45     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-10-02     Completed Date:  1991-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
Dipartimento Scienze e Tecnologie Alimentari e Microbiologiche, University of Milan, Italy.
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MeSH Terms
Acetates / blood
Analysis of Variance
Colon / metabolism*
Dietary Carbohydrates / administration & dosage,  metabolism*
Dietary Fats / administration & dosage,  metabolism*
Food Habits / physiology*
Intestinal Absorption / physiology*
Reg. No./Substance:
0/Acetates; 0/Dietary Carbohydrates; 0/Dietary Fats

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