Document Detail


The combined effects of exercise and foods in preventing neurological and cognitive disorders.
MedLine Citation:
PMID:  21281667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Exercise and select diets have important influences on health and plasticity of the nervous system, and the molecular mechanisms involved with these actions are starting to be elucidated. New evidence indicates that exercise, in combination with dietary factors, exerts its effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity.
METHODS: Published studies in animals and humans describing the effects of exercise and diets in brain plasticity and cognitive abilities are discussed.
RESULTS: New evidence indicates that exercise and select diets exert their effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity. An important instigator in the molecular machinery stimulated by exercise is brain-derived neurotrophic factor (BDNF), which acts at the interface of metabolism and plasticity.
CONCLUSIONS: Recent studies show that selected dietary factors share similar mechanisms with exercise, and in some cases they can complement the action of exercise. Therefore, exercise and dietary management appear as a non-invasive and effective strategy to counteract neurological and cognitive disorders.
Authors:
Fernando Gomez-Pinilla
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-01-31
Journal Detail:
Title:  Preventive medicine     Volume:  52 Suppl 1     ISSN:  1096-0260     ISO Abbreviation:  Prev Med     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-07     Completed Date:  2011-11-15     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0322116     Medline TA:  Prev Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S75-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Injuries
Brain-Derived Neurotrophic Factor / physiology*
Cognition Disorders / prevention & control*
Curcumin / pharmacology
Diet / methods*
Dietary Supplements
Docosahexaenoic Acids / pharmacology
Energy Metabolism
Exercise / physiology*
Fatty Acids, Omega-3 / pharmacology
Food
Humans
Motor Activity / physiology*
Nervous System Diseases / prevention & control*
Neuronal Plasticity / drug effects
Grant Support
ID/Acronym/Agency:
NS068473/NS/NINDS NIH HHS; NS50465-06/NS/NINDS NIH HHS; NS56413/NS/NINDS NIH HHS; R01 NS050465/NS/NINDS NIH HHS; R01 NS050465-06A1/NS/NINDS NIH HHS; R01 NS056413/NS/NINDS NIH HHS; R01 NS056413-03/NS/NINDS NIH HHS; RC1 NS068473/NS/NINDS NIH HHS; RC1 NS068473-02/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Fatty Acids, Omega-3; 25167-62-8/Docosahexaenoic Acids; IT942ZTH98/Curcumin
Comments/Corrections

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