| The combined effects of exercise and foods in preventing neurological and cognitive disorders. | |
MedLine Citation:
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PMID: 21281667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Exercise and select diets have important influences on health and plasticity of the nervous system, and the molecular mechanisms involved with these actions are starting to be elucidated. New evidence indicates that exercise, in combination with dietary factors, exerts its effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity. METHODS: Published studies in animals and humans describing the effects of exercise and diets in brain plasticity and cognitive abilities are discussed. RESULTS: New evidence indicates that exercise and select diets exert their effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity. An important instigator in the molecular machinery stimulated by exercise is brain-derived neurotrophic factor (BDNF), which acts at the interface of metabolism and plasticity. CONCLUSIONS: Recent studies show that selected dietary factors share similar mechanisms with exercise, and in some cases they can complement the action of exercise. Therefore, exercise and dietary management appear as a non-invasive and effective strategy to counteract neurological and cognitive disorders. |
Authors:
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Fernando Gomez-Pinilla |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-01-31 |
Journal Detail:
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Title: Preventive medicine Volume: 52 Suppl 1 ISSN: 1096-0260 ISO Abbreviation: Prev Med Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-07 Completed Date: 2011-11-15 Revised Date: 2013-06-30 |
Medline Journal Info:
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Nlm Unique ID: 0322116 Medline TA: Prev Med Country: United States |
Other Details:
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Languages: eng Pagination: S75-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Dept. of Integrative Biology and Physiology, and Dept. of Neurosurgery, University of California Los Angeles, Los Angeles, CA 90095, USA. fgomezpi@ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Injuries Brain-Derived Neurotrophic Factor / physiology* Cognition Disorders / prevention & control* Curcumin / pharmacology Diet / methods* Dietary Supplements Docosahexaenoic Acids / pharmacology Energy Metabolism Exercise / physiology* Fatty Acids, Omega-3 / pharmacology Food Humans Motor Activity / physiology* Nervous System Diseases / prevention & control* Neuronal Plasticity / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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NS068473/NS/NINDS NIH HHS; NS50465-06/NS/NINDS NIH HHS; NS56413/NS/NINDS NIH HHS; R01 NS050465-06A1/NS/NINDS NIH HHS; R01 NS050465-08/NS/NINDS NIH HHS; R01 NS056413-03/NS/NINDS NIH HHS; RC1 NS068473-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor; 0/Fatty Acids, Omega-3; 25167-62-8/Docosahexaenoic Acids; 458-37-7/Curcumin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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