Document Detail

Intrathecal/intraventricular colistin in external ventricular device-related infections by multi-drug resistant Gram negative bacteria: case reports and review.
MedLine Citation:
PMID:  24728736     Owner:  NLM     Status:  Publisher    
We report three cases of external ventricular derivation infections caused by multidrug-resistant Gram-negative rods and treated successfully with intraventricular colistin. The intrathecal or intraventricular use of colistin have been reported in more than 100 cases without any consensus on dosage, duration and type (monotherapy or combination therapy) of treatment. Based on our comprehensive review of the relevant literature relating to both clinical and pharmacokinetic data, we conclude that the intrathecal/intraventricular administration of colistin is a safe and effective option to treat central nervous system infections caused by multidrug-resistant Gram-negative bacteria.
O Bargiacchi; A Rossati; P Car; D Brustia; R Brondolo; F Rosa; P L Garavelli; F G De Rosa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-12
Journal Detail:
Title:  Infection     Volume:  -     ISSN:  1439-0973     ISO Abbreviation:  Infection     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0365307     Medline TA:  Infection     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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