| A coincidental case of young-onset Parkinson disease and multiple sclerosis. | |
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MedLine Citation:
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PMID: 21881474 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Parkinsonism in patients with multiple sclerosis is rare. Some patients have 2 coincidental diseases, whereas others have a Parkinsonian syndrome symptomatic to demyelinating lesions. CASE REPORT: We describe a 42-year-old female patient who developed left akinetic-rigid Parkinsonian syndrome at the age of 38 years. Brain magnetic resonance imaging revealed multiple white matter hyperintense T2-weighted lesions. DaTSCAN revealed reduced uptake of dopamine transporter in the right striatum. Intravenous corticosteroids were inefficacious. She had major clinical improvement with levodopa and 6 months later developed peak-dose dyskinesias. At the age of 41 years, she presented with a brainstem attack, with complete symptom resolution after intravenous corticosteroids. Subsequent brain magnetic resonance imagings disclosed new inflammatory lesions. Immunomodulatory treatment was started with β-interferon. COMMENTS: In this patient, the presence of an asymmetrical Parkinsonian syndrome, with good response to levodopa, peak-dose dyskinesias, and abnormal DaTSCAN, supports the diagnosis of young-onset Parkinson disease. The multiple sclerosis diagnosis was established based on clinical evidence of time and space dissemination of demyelinating lesions. |
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Authors:
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Joana Damásio; Cristina Ramos; Leandro Valdemar; Ana Martins da Silva; Marina Magalhães |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The neurologist Volume: 17 ISSN: 1074-7931 ISO Abbreviation: Neurologist Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503763 Medline TA: Neurologist Country: United States |
Other Details:
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Languages: eng Pagination: 286-8 Citation Subset: IM |
Affiliation:
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Departments of *Neurology †Neuroradiology, Hospital de Santo António, Centro Hospitalar do Porto, Porto, Portugal. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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