Document Detail

A cohort study of health care workers to assess nosocomial transmissibility of Nipah virus, Malaysia, 1999.
MedLine Citation:
PMID:  11181159     Owner:  NLM     Status:  MEDLINE    
During 1998-1999, an outbreak of Nipah virus encephalitis occurred in Malaysia. To assess the possibility of nosocomial transmission, 338 health care workers (HCWs) exposed and 288 HCWs unexposed to outbreak-related patients were surveyed, and their serum samples were tested for anti-Nipah virus antibody. Needlestick injuries were reported by 12 (3%) HCWs, mucosal surface exposure to body fluids by 39 (11%), and skin exposure to body fluids by 89 (25%). No encephalitis occurred in either group. Three exposed and no unexposed HCWs tested positive by EIA for IgG antibodies. It is likely that these 3 were false positives; no IgM response occurred, and the serum samples were negative for anti-Nipah virus neutralizing antibodies. The risk of nosocomial transmission of Nipah virus appears to be low; however, given the high case-fatality rate and the presence of virus in respiratory secretions and urine of some patients, standard and droplet infection-control practices should be maintained with these patients.
A W Mounts; H Kaur; U D Parashar; T G Ksiazek; D Cannon; J T Arokiasamy; L J Anderson; M S Lye;
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Publication Detail:
Type:  Journal Article     Date:  2001-01-24
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  183     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  810-3     Citation Subset:  AIM; IM    
Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 30333, USA.
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MeSH Terms
Antibodies, Viral / analysis*
Cohort Studies
Cross Infection / transmission*,  virology
Disease Outbreaks
False Positive Reactions
Immunoenzyme Techniques
Immunoglobulin G / blood,  diagnostic use
Infectious Disease Transmission, Patient-to-Professional
Paramyxoviridae Infections / transmission*
Paramyxovirinae / immunology,  isolation & purification*
Risk Factors
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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