Document Detail


A cohort study of haemoglobin and zinc protoporphyrin levels in term Zambian infants: effects of iron stores at birth, complementary food and placental malaria.
MedLine Citation:
PMID:  17671442     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine zinc-protoporphyrin (ZPP) and haemoglobin levels, and to determine predictors of iron deficiency anaemia (IDA) in Zambian infants. SUBJECTS AND METHODS: Ninety-one women and their normal birth weight (NBW) infants were followed bi-monthly during the first 6 months of life, and iron status, food intake, malaria parasitaemia and growth were monitored. At 4 months, the infants were divided into two groups, and the data were analysed according to whether or not they were exclusively breastfed. RESULTS: Almost two-third of infants were born with low iron stores as defined by ZPP levels, and this proportion increased with age. Over 50% had developed IDA by 6 months. Exclusive breastfeeding at 4 months could be a protective factor for IDA (odds ratio (OR): 0.2; 95% confidence interval (CI): 0.0-1.1). Exclusively breastfed infants had higher haemoglobin values at 4 and 6 months (mean difference 0.6; 95% CI: 0.1-1.2 g/dl and mean difference 0.9; 95% CI: 0.2-1.7 g/dl, respectively), compared with infants with early complementary feeding. In univariate analysis, past or chronic placental malaria appeared to be a predictor of IDA at 4 and 6 months, but the significance was lost in multivariate analysis. CONCLUSIONS: Zambian NBW infants are born with low iron stores and have a high risk to develop IDA in the first 6 months of life. Continuation of exclusive breastfeeding after 4 months is associated with a reduction of anaemia. The effect of placental malaria infection on increased risk of infant IDA could not be proven.
Authors:
P F van Rheenen; L T T de Moor; S Eschbach; B J Brabin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-01
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  62     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-03     Completed Date:  2009-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1379-87     Citation Subset:  IM    
Affiliation:
Paediatric Gastroenterology, Department of Paediatrics, University Medical Centre, Groningen, The Netherlands. p.f.vanrheenen@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / blood,  epidemiology*,  etiology
Animals
Breast Feeding / epidemiology
Cohort Studies
Confidence Intervals
Female
Hemoglobins / analysis*
Humans
Infant
Infant Nutritional Physiological Phenomena / physiology*
Infant, Newborn
Malaria / complications,  epidemiology
Male
Nutritional Requirements
Odds Ratio
Placenta / parasitology
Placenta Diseases / blood,  epidemiology,  parasitology
Predictive Value of Tests
Pregnancy
Pregnancy Complications, Parasitic / blood,  epidemiology*
Protoporphyrins / analysis,  blood*
Risk Factors
Weaning
Zambia / epidemiology
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Protoporphyrins; 15442-64-5/zinc protoporphyrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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