Document Detail

A cohort study of duplex Doppler examinations of the carotid artery in primary open angle glaucoma.
MedLine Citation:
PMID:  25289141     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVES: To explore the possibility of pathological change in the common carotid artery at the bifurcation and in the internal carotid artery beyond the bifurcation which could contribute to a reduced diastolic pressure as observed in primary open angle glaucoma.
DESIGN: Duplex ultrasonic examinations of carotid bifurcations were conducted on 80 patients. Carotid artery defects were allocated into three types: no demonstrable flow defects, internal carotid artery abnormalities and disease in the carotid bulb.
SETTING: Bristol Royal Infirmary Vascular Laboratory.
PARTICIPANTS: Eighty patients (mean age 69.6 years) providing a total of 160 sides to the analysis.
MAIN OUTCOME MEASURES: An estimated central retinal artery pressure, intraocular pressure and field loss were recorded for each side measured.
RESULTS: Doppler investigations revealed significant levels of pathological change in the internal carotid distinct from changes at the carotid bulb. The disease revealed in the internal carotid artery was significantly associated with intraocular pressure (p = 0.032), with an effect small to medium in magnitude. The Q2 measure, derived from mean arterial pressure and intraocular pressure, was also substantively associated with disease in the internal carotid artery. Both intraocular pressure and the Q2 measure effectively discriminated between groups, with field loss providing rather less discriminating capability. There was a strong trend towards a higher intraocular pressures and a greater visual field loss with internal carotid artery disease.
CONCLUSIONS: Pathological changes in the extra cranial carotid artery in primary open angle glaucoma exceed those in the arteries classified as normal. The presence of disease specifically in the internal carotid artery emphasised the need for a mechanism for the evaluation of the internal carotid apart from the carotid bulb. A basis for clarifying the presence of an ischaemic zone is proposed.
Vincent J Marmion; Munther I Aldoori; John P Woodcock; John Stephenson
Publication Detail:
Type:  Journal Article     Date:  2014-07-08
Journal Detail:
Title:  JRSM open     Volume:  5     ISSN:  2054-2704     ISO Abbreviation:  JRSM Open     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-10-07     Completed Date:  2014-10-07     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101625786     Medline TA:  JRSM Open     Country:  England    
Other Details:
Languages:  eng     Pagination:  2054270414527933     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multiple or metastatic clear cell chondrosarcoma: a case report.
Next Document:  Therapeutic drug monitoring in a developing nation: a clinical guide.