Document Detail

The cognitive syndrome of vascular dementia: implications for clinical trials.
MedLine Citation:
PMID:  10609678     Owner:  NLM     Status:  MEDLINE    
Dementia is common among patients with cerebrovascular disease, particularly in a setting of one or more clinically evident strokes. Prior cohort and case studies have suggested that the cognitive syndrome of vascular dementia is characterized by predominant executive dysfunction, in contrast to the deficits in memory and language function that are typical of patients with Alzheimer disease. The course of cognitive decline may also differ between those dementia subtypes, with many, but not all, patients with vascular dementia exhibiting a stepwise course of decline caused by recurrent stroke and most patients with Alzheimer disease exhibiting a gradually progressive course of decline. The findings of prior studies of the cognitive syndrome of vascular dementia must be interpreted with caution, however, because of (1) possible inaccuracies in the determination of the dementia subtype and the loss of precision that might result from pooling heterogeneous subgroups of patients with vascular dementia, (2) difficulties inherent in identifying a pattern of strengths and weaknesses in patients who are required to have memory impairment and other deficits to meet operationalized criteria for dementia, and (3) the use of limited test batteries whose psychometric properties are incompletely understood. Specific questions that should be addressed by future studies are discussed.
D W Desmond; T Erkinjuntti; M Sano; J L Cummings; J V Bowler; F Pasquier; J T Moroney; S H Ferris; Y Stern; P S Sachdev; V C Hachinski
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Alzheimer disease and associated disorders     Volume:  13 Suppl 3     ISSN:  0893-0341     ISO Abbreviation:  Alzheimer Dis Assoc Disord     Publication Date:    1999 Oct-Dec
Date Detail:
Created Date:  2000-01-10     Completed Date:  2000-01-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8704771     Medline TA:  Alzheimer Dis Assoc Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S21-9     Citation Subset:  IM    
Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, New York, USA.
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MeSH Terms
Clinical Trials as Topic
Cognition Disorders / etiology*
Cohort Studies
Dementia, Vascular / psychology*
Neurology / methods,  trends
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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