| The coexistence of type 1 diabetes, MODY2 and metabolic syndrome in a young girl. | |
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MedLine Citation:
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PMID: 21688019 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Even though autoantibodies to pancreatic islet cells are normally found in type 1 diabetes and insulin-resistance due to overweight is more reminiscent of type 2 diabetes, some studies have described β-cell antibodies also in maturity-onset diabetes of the young (MODY) and in type 2 diabetes. A 7-year-old girl was referred to our Unit for incidental hyperglycemia and family history of MODY2 and type 2 diabetes. Genetic evaluation confirmed mutation L134P in exon 4 of the glucokinase gene and a high HLA-risk of type 1 diabetes. During follow-up, she developed type 1 diabetes and overweight-induced metabolic syndrome. The coexistence of MODY, type 1 diabetes and overweight-induced metabolic syndrome confirms that diabetes subtype probably represents a continuum of immune and metabolic dysfunction modified by genetic factors. |
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Authors:
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Valeria Calcaterra; Miryam Martinetti; Alessandro Salina; Concetta Aloi; Daniela Larizza |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-18 |
Journal Detail:
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Title: Acta diabetologica Volume: - ISSN: 1432-5233 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200299 Medline TA: Acta Diabetol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, University of Pavia and IRCCS Policlinico San Matteo Foundation, P.le Golgi n.2, 27100, Pavia, Italy, v.calcaterra@smatteo.pv.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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