| The coding-synonymous polymorphism rs1045280 (Ser280Ser) in beta-arrestin 2 (ARRB2) gene is associated with tardive dyskinesia in Chinese patients with schizophrenia. | |
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MedLine Citation:
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PMID: 19049562 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Tardive dyskinesia (TD) is a severe and potentially irreversible adverse effect of long-term antipsychotic treatment. Typical antipsychotics are commonly binding to the dopamine receptor D2 (DRD2), but the occurrence of antipsychotic-induced TD is rather delayed; therefore, the development of TD may be associated with mediators or signalling complexes behind DRD2, such as beta-arrestin 2 (ARRB2), an important mediator between DRD2 and serine-threonine protein kinase (AKT) signal cascade. METHODS: A case-control study to evaluate the association between rs1045280 (Ser280Ser) and antipsychotic-induced TD was performed amongst 381 patients (TD/non-TD = 228/153). RESULTS: There was a significant difference in the genotype distribution between TD and non-TD groups (P = 0.025); furthermore, the allelic analysis indicated that patients with T allele had increased risk of TD occurrence (OR(T) = 1.58, 95% CI = 1.14-2.19, P = 0.007). CONCLUSIONS: To the best of our knowledge, this is the first study reporting a positive association between the SNP rs1045280 and TD in schizophrenic patients. |
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Authors:
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Y-J Liou; Y-C Wang; J-Y Chen; M-L Chen; T-T Chen; Y-M Bai; C-C Lin; D-L Liao; I-C Lai |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 15 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-03 Completed Date: 2009-02-20 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 1406-8 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antipsychotic Agents
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adverse effects* Arrestins / genetics* Asian Continental Ancestry Group Case-Control Studies DNA Mutational Analysis Dyskinesia, Drug-Induced / ethnology, genetics*, metabolism Female Genetic Markers / genetics Genetic Predisposition to Disease / ethnology, genetics* Genetic Testing Humans Male Open Reading Frames / genetics Polymorphism, Genetic / genetics* Proto-Oncogene Proteins c-akt / metabolism Receptors, Dopamine D2 / drug effects, metabolism Schizophrenia / drug therapy* Signal Transduction / drug effects, genetics Taiwan |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Arrestins; 0/Genetic Markers; 0/Receptors, Dopamine D2; 0/beta-arrestin; EC 2.7.11.1/Proto-Oncogene Proteins c-akt |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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