Document Detail


A code for behavioral inhibition on the basis of color, but not motion, in ventrolateral prefrontal cortex of macaque monkey.
MedLine Citation:
PMID:  11425907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine the neural mechanism for behavioral inhibition, we recorded single-cell activity in macaque ventrolateral prefrontal cortex, which is known to receive visual information directly from the inferotemporal cortex. In response to a moving random pattern of colored dots, monkeys had to make a go or no-go response. In the color condition, green indicated go, whereas red indicated no-go, regardless of the motion direction; in the motion condition, upward indicated go, whereas downward indicated no-go, regardless of the color. Approximately one-half of the visual cells were go/no-go differential. A majority of these cells (64/73) showed differential activity only in the color condition; they responded nondifferentially in the motion condition, although the same set of stimuli was used. We classified these cells as "go type" (n = 41) and "no-go type" (n = 23) depending on the color for which they showed a stronger response. Interestingly, in both types of cells, the differential effects were observed only for the no-go-indicating color. Compared with the nondifferential responses in the motion condition, go-type cells in the color condition showed weaker responses to the no-go-indicating color, whereas their responses to the go-indicating color were similar; in contrast, no-go type cells showed stronger responses to the no-go-indicating color, whereas their responses to the go-indicating color were similar. Both types of cells did not show any activity change during the actual execution of the go or no-go response. These results suggest that neurons in ventrolateral prefrontal cortex contribute to stimulus-response association in complex task situations by inhibiting behavioral responses on the basis of visual information from the ventral stream.
Authors:
M Sakagami; Tsutsui Ki; J Lauwereyns; M Koizumi; S Kobayashi; O Hikosaka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  21     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-26     Completed Date:  2001-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4801-8     Citation Subset:  IM    
Affiliation:
Department of Physiology, Juntendo University, School of Medicine, Bunkyo, Tokyo, Japan 113-8421. sakagami@lab.tamagawa.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology*
Choice Behavior / physiology
Color Perception / physiology*
Cues
Discrimination Learning / physiology
Electrodes, Implanted
Evoked Potentials, Visual / physiology
Fixation, Ocular / physiology
Inhibition (Psychology)*
Macaca
Male
Motion Perception / physiology*
Neurons / classification,  physiology
Photic Stimulation
Prefrontal Cortex / cytology,  physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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