Document Detail


A cocaine cue is more preferred and evokes more frequency-modulated 50-kHz ultrasonic vocalizations in rats prone to attribute incentive salience to a food cue.
MedLine Citation:
PMID:  21833503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Individuals vary considerably in the extent to which they attribute incentive salience to food-associated cues.
OBJECTIVES: We asked whether individuals prone to attribute incentive salience to a food cue are also prone to attribute incentive properties to a stimulus associated with a drug of abuse-cocaine.
METHODS: We first identified those rats that attributed incentive salience to a food cue by quantifying the extent to which they came to approach and engage a food cue. We then used a conditioned place preference procedure to pair an injection of 10 mg/kg cocaine (i.p.) with one distinct floor texture (grid or holes) and saline with another. Following 8 days of conditioning, each rat was given a saline injection and placed into a chamber that had both floors present. We measured the time spent on each floor, and also 50-kHz ultrasonic vocalizations, which have been associated with positive affective states.
RESULTS: Rats that vigorously engaged the food cue ("sign trackers") expressed a preference for the cocaine-paired floor compared to those that did not ("goal trackers"). In addition, sign trackers made substantially more frequency-modulated 50-kHz vocalizations when injected with cocaine and when later exposed to the cocaine cue.
CONCLUSIONS: Rats prone to attribute incentive salience to a food cue are also prone to attribute incentive motivational properties to a tactile cue associated with cocaine. We suggest that individuals prone to attribute incentive salience to reward cues will have difficulty resisting them and, therefore, may be especially vulnerable to develop impulse control disorders, including addiction.
Authors:
Paul J Meyer; Sean T Ma; Terry E Robinson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-08-11
Journal Detail:
Title:  Psychopharmacology     Volume:  219     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-26     Completed Date:  2012-05-16     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  999-1009     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cocaine / pharmacology*
Conditioning (Psychology)
Cues*
Feeding Behavior / psychology*
Male
Motivation
Rats
Rats, Sprague-Dawley
Reward*
Ultrasonics
Vocalization, Animal
Grant Support
ID/Acronym/Agency:
R01 DA004294/DA/NIDA NIH HHS; R37 DA04294/DA/NIDA NIH HHS; T32 DA007268/DA/NIDA NIH HHS; T32 DA007268/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
I5Y540LHVR/Cocaine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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