Document Detail


The co-occurrence of serologically proven myasthenia gravis and Miller Fisher/Guillain Barré overlap syndrome: a case report.
MedLine Citation:
PMID:  18804791     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The co-occurrence of myasthenia gravis (MG) and Guillain Barré syndrome (GBS) is uncommon with a few reported cases in the literature. There is only one reported case of MG and Miller Fisher variant of GBS. We described an 84 year old Chinese woman with underlying seropositive myasthenia gravis (MG) who presented with ophthalmoplegia, areflexia and acute neuromuscular weakness. She was proved to have co-occurrence of MG and GBS/Miller Fisher overlap syndrome with positive anti-GQ1b antibody. The unusual finding in this patient raises an interesting question on their pathogenesis with the possibility that prior activation of the immune system may predispose the development of autoantibodies against other antigens within the same set of muscles.
Authors:
Kwok Kwong Lau; Khean Jin Goh; Han Chih Hencher Lee; Yuk Tat Eric Chan; Chong Tin Tan
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-09-19
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  276     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-12     Completed Date:  2009-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  187-8     Citation Subset:  IM    
Affiliation:
Department of Medicine and Geriatrics, Princess Margaret Hospital, Kwai Chung, New Territories, Hong Kong. dominickklau@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged, 80 and over
Antibodies / blood
Female
Gangliosides / immunology
Guillain-Barre Syndrome / complications*,  immunology*
Humans
Myasthenia Gravis / complications*,  immunology*
Serologic Tests / methods*
Chemical
Reg. No./Substance:
0/Antibodies; 0/Gangliosides; 68652-37-9/GQ1b ganglioside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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