Document Detail

A co-housing strategy to improve fecundity of mice in timed matings.
MedLine Citation:
PMID:  23340789     Owner:  NLM     Status:  MEDLINE    
Timed matings of mice are often carried out to obtain offspring of a precise age when required for a study. Timed matings involve housing male and female mice together for a limited time period, typically overnight. A limitation of this practice is that many mouse pairs fail to mate during the brief co-housing period. The authors co-housed each breeding pair in the same cage but separated by a transparent partition for 3 d before carrying out timed matings. This co-housing strategy resulted in increased copulation during the timed mating period and also significantly increased the average number of pups produced per breeding pair. The authors suggest that co-housing likely permits male urine-borne pheromones to induce female estrus and also enables the expression of male and female mating behaviors.
Robert J Stiles; Adam G Schrum; Diana Gil
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lab animal     Volume:  42     ISSN:  1548-4475     ISO Abbreviation:  Lab Anim (NY)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-23     Completed Date:  2013-11-11     Revised Date:  2014-03-03    
Medline Journal Info:
Nlm Unique ID:  0417737     Medline TA:  Lab Anim (NY)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-5     Citation Subset:  IM    
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MeSH Terms
Breeding / methods*
Fertility / physiology*
Housing, Animal*
Laboratory Animal Science
Litter Size
Mice, Inbred C57BL
Sexual Behavior, Animal / physiology*
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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