| Chitosan/poly(DL,lactide-co-glycolide) scaffolds for tissue engineering. | |
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MedLine Citation:
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PMID: 22960878 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chitosan/poly(DL-lactide-co-glycolide) (Ch/DL PLG) composite scaffolds were fabricated by freeze-drying lyophilization, and were evaluated and compared for use as a bone regeneration scaffold through measurements of the compression mechanical properties of the porous scaffolds. Also, In vitro cell culture of Sprague-Dawley rat's osteoblasts were used to evaluate the phenotype expression of cells in the scaffolds, characterizing the cellular adhesion, proliferation and alkaline phosphatase activity. The gene expression of osteocalcin, sialoprotein, alkaline phosphatase, Type I collagen and TGFβ1 were confirmed in the samples; moreover, it was confirmed, the mineralization by IR spectra and EDS analysis. Our results thus show that Ch/DL PLG scaffolds are suitable for biological applications. |
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Authors:
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S A Martel-Estrada; I Olivas-Armendáriz; C A Martínez-Pérez; T Hernández; E I Acosta-Gómez; J G Chacón-Nava; F Jiménez-Vega; P E García-Casillas |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-9 |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: - ISSN: 1573-4838 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Instituto de Ingeniería y Tecnología, Universidad Autónoma de Cd. Juárez, Av. Del Charro 450 Norte, Col. Partido Romero, 32310, Cd. Juárez, CHIH, Mexico, mizul@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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