| The clustering of disorders in infants born before the 28th week of gestation. | |
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MedLine Citation:
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PMID: 20712837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To see whether disorders prevalent in infants born extremely preterm cluster. DESIGN: Observational cohort study. SETTING: University-affiliated newborn intensive care nurseries. SUBJECTS: One thousand two hundred and twenty-three infants born before the 28th week of gestation who survived until 36 weeks postmenstrual age when the diagnosis of bronchopulmonary dysplasia (BPD) could be made. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Cerebral white matter damage (an echolucent lesion, or moderate or severe ventriculomegaly on a protocol cranial ultrasound scan), BPD, retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC) and early and late bacteremia. RESULTS: After adjustment for gestational age, children who had severe NEC (Bell stage IIIb) were at increased risk of cerebral white matter damage, severe ROP (stage 3+), and severe BPD (defined as both oxygen and ventilator dependent). Children who had early bacteremia were at increased risk of late bacteremia and severe ROP. Those who had severe ROP were at increased risk of severe BPD and both early and late bacteremia. CONCLUSIONS: Necrotizing enterocolitis is the disorder common to most of the clusters, but we do not know if its onset occurred before the others. Organ-damage-promoting substances, however, have been found in the circulation of newborn animals with bowel inflammation, supporting the view that NEC contributes to the damage of other organs. |
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Authors:
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Alan Leviton; Olaf Dammann; Stephen Engelke; Elizabeth Allred; Karl C K Kuban; T Michael O'Shea; Nigel Paneth; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-06 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 99 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1795-800 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s)/Acta Paediatrica © 2010 Foundation Acta Paediatrica. |
Affiliation:
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Neurology Department, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA. alan.leviton@childrens.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacteremia
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diagnosis,
epidemiology Bronchopulmonary Dysplasia / diagnosis, epidemiology Cerebral Cortex / pathology Cluster Analysis Cohort Studies Enterocolitis, Necrotizing / diagnosis, epidemiology Gestational Age* Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / diagnosis*, epidemiology* Retinopathy of Prematurity / diagnosis, epidemiology Risk Assessment Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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5U01NS040069-05/NS/NINDS NIH HHS; P30-HD-18655/HD/NICHD NIH HHS |
| Investigator | |
Investigator/Affiliation:
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Kathleen Lee / ; Anne McGovern / ; Susan Ursprung / ; Bhavesh Shah / ; Karen Christianson / ; Camilia R Martin / ; Linda J Van Marter / ; Robert M Insoft / ; Maureen Quill / ; Cynthia Cole / ; John M Fiascone / ; Ellen Nylen / ; Francis Bednarek / ; Beth Powers / ; Mary Naples / ; Richard Ehrenkranz / ; Joanne Williams / ; Teresa Harold / ; Deborah Hiatt / ; Sherry Moseley / ; Carl Bose / ; Gennie Bose / ; Mariel Poortenga / ; Dinah Sutton / ; Nicholas Olomu / ; Carolyn Solomon / ; Madeleine Lenski / ; Padmani Karna / ; Michael D Schreiber / ; Grace Yoon / ; Daniel Batton / ; Beth Kring / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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