Document Detail

The clustering of disorders in infants born before the 28th week of gestation.
MedLine Citation:
PMID:  20712837     Owner:  NLM     Status:  MEDLINE    
AIM: To see whether disorders prevalent in infants born extremely preterm cluster.
DESIGN: Observational cohort study.
SETTING:   University-affiliated newborn intensive care nurseries.
SUBJECTS:   One thousand two hundred and twenty-three infants born before the 28th week of gestation who survived until 36 weeks postmenstrual age when the diagnosis of bronchopulmonary dysplasia (BPD) could be made.
MAIN OUTCOME MEASURES:   Cerebral white matter damage (an echolucent lesion, or moderate or severe ventriculomegaly on a protocol cranial ultrasound scan), BPD, retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC) and early and late bacteremia.
RESULTS: After adjustment for gestational age, children who had severe NEC (Bell stage IIIb) were at increased risk of cerebral white matter damage, severe ROP (stage 3+), and severe BPD (defined as both oxygen and ventilator dependent). Children who had early bacteremia were at increased risk of late bacteremia and severe ROP. Those who had severe ROP were at increased risk of severe BPD and both early and late bacteremia.
CONCLUSIONS:   Necrotizing enterocolitis is the disorder common to most of the clusters, but we do not know if its onset occurred before the others. Organ-damage-promoting substances, however, have been found in the circulation of newborn animals with bowel inflammation, supporting the view that NEC contributes to the damage of other organs.
Alan Leviton; Olaf Dammann; Stephen Engelke; Elizabeth Allred; Karl C K Kuban; T Michael O'Shea; Nigel Paneth;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-09-06
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  99     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1795-800     Citation Subset:  IM    
Copyright Information:
© 2010 The Author(s)/Acta Paediatrica © 2010 Foundation Acta Paediatrica.
Neurology Department, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Bacteremia / diagnosis,  epidemiology
Bronchopulmonary Dysplasia / diagnosis,  epidemiology
Cerebral Cortex / pathology
Cluster Analysis
Cohort Studies
Enterocolitis, Necrotizing / diagnosis,  epidemiology
Gestational Age*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / diagnosis*,  epidemiology*
Retinopathy of Prematurity / diagnosis,  epidemiology
Risk Assessment
Severity of Illness Index
Grant Support
Kathleen Lee / ; Anne McGovern / ; Susan Ursprung / ; Bhavesh Shah / ; Karen Christianson / ; Camilia R Martin / ; Linda J Van Marter / ; Robert M Insoft / ; Maureen Quill / ; Cynthia Cole / ; John M Fiascone / ; Ellen Nylen / ; Francis Bednarek / ; Beth Powers / ; Mary Naples / ; Richard Ehrenkranz / ; Joanne Williams / ; Teresa Harold / ; Deborah Hiatt / ; Sherry Moseley / ; Carl Bose / ; Gennie Bose / ; Mariel Poortenga / ; Dinah Sutton / ; Nicholas Olomu / ; Carolyn Solomon / ; Madeleine Lenski / ; Padmani Karna / ; Michael D Schreiber / ; Grace Yoon / ; Daniel Batton / ; Beth Kring /

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