Document Detail

A cluster study of gastroschisis: single center experience.
MedLine Citation:
PMID:  18783039     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND METHODS: A cluster of 10 neonates admitted with a diagnosis of gastroschisis at birth to the Neonatal Intensive Care Unit (NICU) at the University of Kentucky Medical Center in the year 1996, prompted us to perform a retrospective analysis to determine environmental or genetic causes. RESULTS: A total of 36 neonates with gastroschisis were admitted during the period 1/1992 to 12/1996, and the maternal and patient demographics were evaluated by chart review. The mean maternal age was 21.5 years (14-35 years) of which 42% were teenagers, 66% were primiparous, 42% were smokers, 6% had a history of illicit drug use, and 72% had a history of taking prenatal vitamins. Mean birth weight was 2438g (990-3700g) with 54% being preterm with a mean gestational age of 36 wks (29-40 wks). Family history was negative and chromosomes were normal in patients in whom a karyotype was performed (25%). There was no recurring environmental or drug exposure in the study group. The mothers were from 24 different counties of Kentucky. The 36 cases were not uniformly distributed over the five-year period (chi square statistic = 46.8, degrees of freedom = 4, p < 0.0001). However, there was no evidence that the cases clustered in any 1 year (p = 0.99 for Ederer-Myers-Mantel test). CONCLUSIONS: This is one of the few cluster studies of babies born with gastroschisis. Many of the mothers were teenagers, primiparous, and had an increased frequency of smoking. There was no evidence of temporal or spatial clustering in the gastroschisis cases. We conclude that the cluster of gastroschisis cases in our study occurred as a matter of chance.
Shilpi Chabra; Bryan D Hall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Kentucky Medical Association     Volume:  106     ISSN:  0023-0294     ISO Abbreviation:  J Ky Med Assoc     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-11     Completed Date:  2008-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505615     Medline TA:  J Ky Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-5     Citation Subset:  IM    
Department of Pediatrics, Box 356320, University of Washington, Seattle, WA 98195, USA.
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MeSH Terms
Cluster Analysis
Gastroschisis / epidemiology,  etiology*,  genetics
Infant, Newborn
Intensive Care Units, Neonatal
Kentucky / epidemiology
Maternal Age
Medical Records
Retrospective Studies
Smoking / adverse effects,  epidemiology
Substance-Related Disorders / complications,  epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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