Document Detail


A cluster of coagulase-negative staphylococcal bacteremias associated with peripheral vascular catheter colonization in a neonatal intensive care unit.
MedLine Citation:
PMID:  8442517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A cluster of six neonatal cases of coagulase-negative staphylococcal bacteremias occurred in a Los Angeles County neonatal intensive care unit in March 1989. METHODS: A retrospective cohort study assessed the impact of host-and delivery-related variables, length of hospitalization, duration of antibiotic treatment, performance or duration of invasive procedures, and staffing variables on risk of coagulase-negative staphylococcal bacteremia. RESULTS: Unstratified analyses yielded eight risk factors with risk ratios greater than 2. After stratification by gestational age (less than 29 weeks) and low birth weight (less than 1500 gm), frequency of blood transfusions, duration of respiratory therapy, heparin lock and central vascular line placement, and hyperalimentation remained associated with elevated risk. Two species were identified, arguing against a common source of infection. Of four cohort months with more than 15 very low birth weight infants in the neonatal intensive care unit, an elevation of coagulase-negative staphylococcus-positive blood cultures and diagnosed bacteremias occurred in only two. CONCLUSIONS: This cluster of coagulase-negative staphylococcal bacteremia was probably caused by frequent manipulation of catheters in neonates who were at heightened risk because of low birth weight and prematurity.
Authors:
G A Gellert; D P Ewert; N Bendana; E Smith; C Beck-Sague; A Chin; J M Miller; G Hancock; W Welch; L Mascola
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of infection control     Volume:  21     ISSN:  0196-6553     ISO Abbreviation:  Am J Infect Control     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-29     Completed Date:  1993-03-29     Revised Date:  2009-08-14    
Medline Journal Info:
Nlm Unique ID:  8004854     Medline TA:  Am J Infect Control     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Affiliation:
Orange County Health Care Agency, Santa Ana, CA 92701.
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MeSH Terms
Descriptor/Qualifier:
Bacteremia / epidemiology*
California / epidemiology
Catheterization, Peripheral / adverse effects*
Cluster Analysis
Coagulase
Cohort Studies
Equipment Contamination
Female
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology
Intensive Care Units, Neonatal / statistics & numerical data*
Male
Retrospective Studies
Risk Factors
Staphylococcal Infections / epidemiology*
Chemical
Reg. No./Substance:
0/Coagulase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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