Document Detail


The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development.
MedLine Citation:
PMID:  20646169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of the mouse CNS was reported to be normal in the absence of either Sox4 or its close relative Sox11 despite strong and widespread expression of both transcription factors. In this study, we show that combined absence of both Sox proteins in the mouse leads to severe hypoplasia of the developing spinal cord. Proliferation of neuroepithelial precursor cells in the ventricular zone was unaffected. These cells also acquired their correct positional identity. Both glial and neuronal progenitors were generated and neurons appeared in a similar spatiotemporal pattern as in the wild-type. Rates of cell death were however dramatically increased throughout embryogenesis in the double deficient spinal cord arguing that Sox4 and Sox11 are jointly and redundantly required for cell survival. The absence of pronounced proliferation, patterning, specification, and maturation defects furthermore indicates that the decreased cell survival is not a secondary effect of one of these events. We therefore conclude that the two Sox proteins directly function as pro-survival factors during spinal cord development in neural cell types.
Authors:
Daniela C Thein; Johannes M Thalhammer; Anna C Hartwig; E Bryan Crenshaw; Veronique Lefebvre; Michael Wegner; Elisabeth Sock
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-03
Journal Detail:
Title:  Journal of neurochemistry     Volume:  115     ISSN:  1471-4159     ISO Abbreviation:  J. Neurochem.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-15     Completed Date:  2010-10-13     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  131-41     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal Compilation © 2010 International Society for Neurochemistry.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Death / genetics,  physiology
Cell Proliferation
Cell Size
Cell Survival / genetics,  physiology*
Embryonic Stem Cells / drug effects,  physiology
Gene Deletion
Immunohistochemistry
In Situ Hybridization
In Situ Nick-End Labeling
Mice
Mice, Inbred C57BL
Mice, Knockout
SOXC Transcription Factors / genetics,  physiology*
Spinal Cord / cytology,  growth & development*
Grant Support
ID/Acronym/Agency:
R01 AR054153/AR/NIAMS NIH HHS; R01-AR54153/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/SOXC Transcription Factors; 0/Sox11 protein, mouse; 0/Sox4 protein, mouse
Comments/Corrections

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