| A close association of abnormal iron metabolism with steatosis in the mice fed a choline-deficient diet. | |
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MedLine Citation:
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PMID: 20606296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatic iron overload has been frequently observed in the liver of patients with chronic liver diseases. In this study, the effect of hepatic fatty acid accumulation on the iron metabolism was investigated. Mice fed a choline-deficient diet developed severe steatosis associated with increased total amount of non-heme iron in the liver. Hepatic lipid contents were well correlated with the iron amount. The choline-deficient diet significantly downregulated hepcidin while increases in hemojuvelin and transferrin receptor 2 and a decrease in Tmprss6 expression were observed. Moreover, ferroportin expression was downregulated in the livers of choline-deficient mice while increases in transferrin receptor 1 and divalent metal transporter 1 and a decrease in ferritin expression were observed in accordance with increased hepatic iron content. The expression of hepcidin and ferroportin mRNA was negatively correlated to hepatic lipid concentrations. These results suggest that enhanced dietary iron intake and reduced hepatic iron efflux occur in the mice fed a choline-deficient diet. In addition, a possible link between hepatic iron and lipid metabolism is also suggested. |
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Authors:
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Hiroyuki Tsuchiya; Tomohiko Sakabe; Yuji Akechi; Remina Ikeda; Ren Nishio; Kei Terabayashi; Yoshiaki Matsumi; Yoshiko Hoshikawa; Akihiro Kurimasa; Goshi Shiota |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 33 ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-07 Completed Date: 2010-11-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 1101-4 Citation Subset: IM |
Affiliation:
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Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Yonago, Tottori 683-8504, Japan. tsuchiya@med.tottori-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Choline / administration & dosage* Choline Deficiency / genetics, metabolism* Fatty Liver / genetics, metabolism* Gene Expression Regulation Iron / metabolism* Lipid Metabolism Male Mice Mice, Inbred C57BL |
| Chemical | |
Reg. No./Substance:
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62-49-7/Choline; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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