Document Detail


The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26.
MedLine Citation:
PMID:  1769657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyryl-cholinesterase remains unknown. An atypical form of butyrylcholinesterase or the absence of its activity leads to prolonged apnea following administration of the muscle relaxant suxamethonium. Inheritance of these butyrylcholinesterase variants is consistent with the enzyme activity being encoded in a single autosomal locus, BCHE (formerly CHE1 and E1), which has been assigned to chromosome 3. Previous in situ hybridization of a BCHE cDNA probe gave evidence of homologous sequences at 3q26 and 16q11-q23, raising the possibility of more than one locus coding for butyrylcholinesterase [H. Soreq, R. Zamir, D. Zevin-Sonkin, and H. Zakut (1987) Hum. Genet. 77: 325-328]. Using a different cDNA probe hybridized in situ to 46,XX,inv(3)(p25q21) metaphase chromosomes, we report here the localization of BCHE to a single autosomal location: 3q26.
Authors:
P W Allderdice; H A Gardner; D Galutira; O Lockridge; B N LaDu; P J McAlpine
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  11     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-02-21     Completed Date:  1992-02-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  452-4     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
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MeSH Terms
Descriptor/Qualifier:
Autoradiography
Butyrylcholinesterase / genetics*
Cells, Cultured
Chromosome Inversion
Chromosome Mapping
Chromosomes, Human, Pair 3*
Cloning, Molecular
DNA Probes
Humans
Karyotyping
Lymphocytes
Nucleic Acid Hybridization
Grant Support
ID/Acronym/Agency:
GM27028/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/DNA Probes; EC 3.1.1.-/Butyrylcholinesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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