Document Detail


A clomiphene citrate and tamoxifen citrate combination therapy: a novel therapy for ovulation induction.
MedLine Citation:
PMID:  8486198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the efficacy of a clomiphene citrate (CC) and tamoxifen citrate (CC/tamoxifen) combination therapy in ovulation induction by comparing with a CC alone therapy. DESIGN: A randomized cross-over study with CC alone and CC/tamoxifen combination therapies for 20 normoprolactinemic anovulatory women. Randomly selected 10 of the 20 women (group A) underwent a CC alone therapy (100 mg CC during cycle days 5 to 9) for the initial three consecutive treatment cycles and a CC/tamoxifen combination therapy (50 mg CC and 20 mg tamoxifen during cycle days 5 to 9) for the subsequent three consecutive treatment cycles. The remaining 10 (group B) were treated similarly but with the inverse sequence. Ovulation was documented when a high BBT phase persisted for 11 days or more, when midluteal serum P levels exceeded 7 ng/mL (22.3 nmol/L), or when pregnancy ensued. RESULTS: The rates of ovulatory/treated, pregnant/treated, and pregnant/ovulatory cycles were 42 of 56 (75.0%), 3 of 47 (6.4%), and 3 of 35 (8.6%) for CC/tamoxifen, respectively. Those were 25 of 57 (43.9%), 1 of 48 (2.1%), and 1 of 21 (4.8%) for CC, respectively. Clomiphene citrate/tamoxifen was more effective in ovulation induction than CC. All the pregnancies were normal and single. None of the treatments was accompanied by any remarkable side effects. CONCLUSION: Clomiphene citrate/tamoxifen is a novel treatment modality of ovulation induction with high efficacy.
Authors:
H Suginami; H Kitagawa; N Nakahashi; K Yano; K Matsubara
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fertility and sterility     Volume:  59     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-04     Completed Date:  1993-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  976-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Ehime University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Androgens / blood
Anovulation / blood,  drug therapy*
Clomiphene / therapeutic use*
Drug Therapy, Combination
Estrogens / blood
Female
Follicle Stimulating Hormone / blood
Humans
Luteinizing Hormone / blood
Ovulation Induction*
Pregnancy
Progesterone / blood
Prolactin / blood
Tamoxifen / therapeutic use*
Chemical
Reg. No./Substance:
0/Androgens; 0/Estrogens; 10540-29-1/Tamoxifen; 57-83-0/Progesterone; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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