Document Detail


The clock shop: coupled circadian oscillators.
MedLine Citation:
PMID:  23099412     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Daily rhythms in neural activity underlie circadian rhythms in sleep-wake and other daily behaviors. The cells within the mammalian suprachiasmatic nucleus (SCN) are intrinsically capable of 24-h timekeeping. These cells synchronize with each other and with local environmental cycles to drive coherent rhythms in daily behaviors. Recent studies have identified a small number of neuropeptides critical for this ability to synchronize and sustain coordinated daily rhythms. This review highlights the roles of specific intracellular and intercellular signals within the SCN that underlie circadian synchrony.
Authors:
Daniel Granados-Fuentes; Erik D Herzog
Publication Detail:
Type:  Journal Article; Review     Date:  2012-10-23
Journal Detail:
Title:  Experimental neurology     Volume:  243     ISSN:  1090-2430     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-25     Completed Date:  2013-05-14     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Circadian Clocks / physiology*
Circadian Rhythm / physiology*
Humans
Signal Transduction / physiology
Sleep / physiology
Sleep Disorders / physiopathology
Suprachiasmatic Nucleus / physiology*
Grant Support
ID/Acronym/Agency:
R01 GM096873/GM/NIGMS NIH HHS; R01 MH063104/MH/NIMH NIH HHS
Comments/Corrections

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