Document Detail

The clock in the dorsal suprachiasmatic nucleus runs faster than that in the ventral.
MedLine Citation:
PMID:  15579176     Owner:  NLM     Status:  MEDLINE    
In mammals, circadian rhythms are driven by a pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. The pacemaker is composed of an ensemble of multiple, single-cell oscillators in the SCN. We measured arginine-vasopressin (AVP) release in organotypic SCN slices. The SCN slice culture showed circadian oscillation of AVP release with a period length (+/- SEM) of 23.84 +/- 00.03 h. This period is very similar to the one we previously reported in dispersed SCN cultures and is also close to that of behavioural rhythms. When the ventral part was removed by a surgical cut across the slice in the horizontal plane, however, the period became shorter (23.22 +/- 00.08 h). On the other hand, the removal of the dorsal part did not affect period length. These results suggest that the oscillators in ventral and dorsal cells contribute differently to period length and that the dorsal oscillators are entrained by the ventral ones to form a single integrated oscillator.
Takako Noguchi; Kazuto Watanabe; Akihiko Ogura; Sadao Yamaoka
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  20     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-06     Completed Date:  2005-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  3199-202     Citation Subset:  IM    
Department of Physiology, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan.
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MeSH Terms
Animals, Newborn
Arginine Vasopressin / metabolism*
Circadian Rhythm / physiology*
Rats, Sprague-Dawley
Suprachiasmatic Nucleus / anatomy & histology,  physiology*
Ventral Thalamic Nuclei / physiology*
Reg. No./Substance:
113-79-1/Arginine Vasopressin

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