Document Detail

The clinicopathological significance of the expression of Granzyme B in oral squamous cell carcinoma.
MedLine Citation:
PMID:  20060355     Owner:  NLM     Status:  MEDLINE    
Granzyme B (GB) is a serine protease synthesized by activated cytotoxic T-lymphocytes and natural killer cells that induces neoplastic cells apoptosis. The expression of GB in the tumor microenvironment has been considered a favorable prognostic factor in several types of human cancers. Thus, the aim of this study was to evaluate the density of GB(+) cells in samples of oral cavity squamous cell carcinoma (OCSCC), as well as their relationship with clinical and microscopic parameters. GB expression was analyzed in 55 cases of OCSCC and metastatic and non-metastatic lymph nodes by means of immunohistochemistry. The high density of GB(+) cells demonstrated an association with the high percentage of Bax(+) and annexin V(+) neoplastic cells. In addition, the number of peritumoral GB(+) cells was significantly higher in the OCSCC group without lymph node metastasis, when compared with the metastatic OCSCC group. Moreover, patients with OCSCC with a high density of peritumoral GB(+) cells showed a longer survival time when compared with patients with a lower density of these cells. In lymph node tissues, the density of GB(+) cells was significantly higher in non-metastatic lymph nodes than in metastatic lymph nodes. Our findings suggest that the increased of expression of GB in the tumor microenvironment of OCSCC and in lymph nodes may have beneficial effect against neoplastic cells, contributing to apoptosis of these cells and increased survival of patients.
Nádia Lago Costa; Rita de Cássia Gonçalves Alencar; Marize Campos Valadares; Tarcília Aparecida Silva; Elismauro Francisco Mendonça; Aline Carvalho Batista
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-08
Journal Detail:
Title:  Oral oncology     Volume:  46     ISSN:  1879-0593     ISO Abbreviation:  Oral Oncol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-23     Completed Date:  2011-03-31     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  185-9     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier Ltd. All rights reserved.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / enzymology*,  mortality,  secondary
Gene Expression Regulation, Neoplastic
Granzymes / genetics,  metabolism*
Lymphatic Metastasis
Middle Aged
Mouth Neoplasms / enzymology*,  mortality,  pathology
Neoplasm Proteins / metabolism*
Retrospective Studies
Survival Analysis
T-Lymphocytes, Cytotoxic / enzymology*
Reg. No./Substance:
0/Neoplasm Proteins; EC 3.4.21.-/Granzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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