| A clinically relevant model of heart failure: effects of ticlopidine. | |
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MedLine Citation:
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PMID: 4005894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A clinically relevant model of heart failure has been developed in chronically instrumented mini-pigs by injecting Sephadex beads into the left main or circumflex coronary arteries under fluoroscopic control. In six control animals, left atrial pressure (LAP) increased from 10 +/- 2 to 19 +/- 2 mmHg (p less than 0.01) and remained elevated for 3 days. Heart rate increased by 26 beats X min-1 (p less than 0.05) and diastolic pressure fell after 24 h but recovered over the next 48 h. In six animals treated with ticlopidine (50 mg X kg-1 p.o.) for four days prior to embolisation, the acute haemodynamic changes were less in the first day but similar to control after 3 days. Infarct size was approximately 20% of the left ventricle in control animals and 9.5% in the treated group (p less than 0.01). ADP-induced platelet activity was reduced in the treated animals suggesting that coronary occlusion followed both physical occlusion by the beads and later development of platelet thrombi. |
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Authors:
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A Nuttall; H J Smith; B E Loveday |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular research Volume: 19 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-08-20 Completed Date: 1985-08-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 187-92 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Coronary Circulation Disease Models, Animal* Embolism / complications Female Heart Failure / etiology*, physiopathology Heart Rate Male Platelet Aggregation / drug effects Swine Thiophenes / pharmacology* Ticlopidine |
| Chemical | |
Reg. No./Substance:
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0/Thiophenes; 55142-85-3/Ticlopidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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