| The clinical value of digoxin in patients with heart failure and sinus rhythm. | |
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MedLine Citation:
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PMID: 751085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Six patients in sinus rhythm with congestive heart failure due to either myocardial infarction or cardiomyopathy, were given oral frusemide to eliminate oedema. Symptomatic relief occurred as body weight was reduced, and after a 'dry' basal weight had been achieved, progressive-load exercise testing was done to examine any benefit that derived from adding oral digoxin to the diuretic. Three pairs of sub-maximal exercise tests were done at intervals over three months, and the responses of each patient when using digoxin and diuretics were compared with those when using diuretics alone. One patient did not complete this study, because more frequent premature beats and increased angina followed the withdrawal of digoxin. For the five patients who completed three pairs of tests, there was no significant change in symptoms, in workload achieved, or in heart rate, respiratory rate, ventilation and respiratory quotient, whether digoxin was added or removed. It is concluded that in these patients where salt and water retention was controlled with diuretics, digoxin did not improve the capacity for exercise, and it is suggested that for such patients with myocardial disease in sinus rhythm, treatment should begin with diuretics. |
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Authors:
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D McHaffie; H Purcell; P Mitchell-Heggs; A Guz |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Quarterly journal of medicine Volume: 47 ISSN: 0033-5622 ISO Abbreviation: Q. J. Med. Publication Date: 1978 Oct |
Date Detail:
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Created Date: 1979-07-25 Completed Date: 1979-07-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401027 Medline TA: Q J Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 401-19 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arrhythmia, Sinus / drug therapy*, physiopathology Body Water / analysis Body Weight Digoxin / blood, therapeutic use* Drug Therapy, Combination Exercise Test Female Furosemide / therapeutic use Heart Failure / drug therapy*, physiopathology Humans Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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20830-75-5/Digoxin; 54-31-9/Furosemide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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