Document Detail

The clinical value of digoxin in patients with heart failure and sinus rhythm.
MedLine Citation:
PMID:  751085     Owner:  NLM     Status:  MEDLINE    
Six patients in sinus rhythm with congestive heart failure due to either myocardial infarction or cardiomyopathy, were given oral frusemide to eliminate oedema. Symptomatic relief occurred as body weight was reduced, and after a 'dry' basal weight had been achieved, progressive-load exercise testing was done to examine any benefit that derived from adding oral digoxin to the diuretic. Three pairs of sub-maximal exercise tests were done at intervals over three months, and the responses of each patient when using digoxin and diuretics were compared with those when using diuretics alone. One patient did not complete this study, because more frequent premature beats and increased angina followed the withdrawal of digoxin. For the five patients who completed three pairs of tests, there was no significant change in symptoms, in workload achieved, or in heart rate, respiratory rate, ventilation and respiratory quotient, whether digoxin was added or removed. It is concluded that in these patients where salt and water retention was controlled with diuretics, digoxin did not improve the capacity for exercise, and it is suggested that for such patients with myocardial disease in sinus rhythm, treatment should begin with diuretics.
D McHaffie; H Purcell; P Mitchell-Heggs; A Guz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Quarterly journal of medicine     Volume:  47     ISSN:  0033-5622     ISO Abbreviation:  Q. J. Med.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-07-25     Completed Date:  1979-07-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401027     Medline TA:  Q J Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  401-19     Citation Subset:  IM    
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MeSH Terms
Arrhythmia, Sinus / drug therapy*,  physiopathology
Body Water / analysis
Body Weight
Digoxin / blood,  therapeutic use*
Drug Therapy, Combination
Exercise Test
Furosemide / therapeutic use
Heart Failure / drug therapy*,  physiopathology
Middle Aged
Reg. No./Substance:
20830-75-5/Digoxin; 54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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