| The clinical value of 18F-FDG PET/CT for investigating unexplained serum AFP elevation following interventional therapy for hepatocellular carcinom. | |
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MedLine Citation:
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PMID: 19760952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: The goal of this study was to assess the clinical usefulness of 18F-FDG PET/ CT for investigating unexplained serum AFP elevation following interventional therapy such as transarterial chemoembolization (TAE) or radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). METHODOLOGY: A retrospective study was conducted involving 18 HCC patients (9 men and 9 women; age, 42-67 years) who underwent 18F-FDG PET/CT for evaluation of AFP without evidence of HCC recurrence on multiphasic abdominal CT after TAE or RFA treatment. The results of the 18F-FDG PET/CT were compared with histological, radiological and clinical follow-up. RESULTS: Among 18 patients, 14 patients demonstrated HCC recurrence (10 intrahepatic, 3 extrahepatic and 1 intrahepatic/extrahepatic). Metastatic foci were found in the lung (1 patient), bone (1 patient), lymph node (1 patient), and adrenal gland (1 patient). The 18F-FDG PET/CT identified seven intrahepatic and four extrahepatic lesions. Overall, the 18F-FDG PET/CT had nine true-positives, five false-negatives, four true-negatives and zero false-positives for the detection of HCC recurrence. The sensitivity, specificity and accuracy were 64%, 100% and 72%, respectively. CONCLUSIONS: When the multiphasic CT was normal, the 18F-FDG PET/CT was valuable to reveal intrahepatic tumor recurrence and/or extrahepatic metastases in patients with AFP elevation after interventional therapy for HCC. |
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Authors:
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A-Reum Han; Geum-Youn Gwak; Moon Seok Choi; Joon Hyeok Lee; Kwang Cheol Koh; Seung Woon Paik; Byung Chul Yoo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 56 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-09-17 Completed Date: 2009-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 1111-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Hepatocellular / blood*, radiography*, radionuclide imaging*, therapy Catheter Ablation Chemoembolization, Therapeutic Female Fluorodeoxyglucose F18 / diagnostic use Humans Liver Neoplasms / blood*, radiography*, radionuclide imaging*, therapy Male Middle Aged Neoplasm Recurrence, Local / blood, radiography, radionuclide imaging Predictive Value of Tests Radiopharmaceuticals / diagnostic use Retrospective Studies Sensitivity and Specificity Tomography, Emission-Computed* Tomography, X-Ray Computed* Tumor Markers, Biological / blood alpha-Fetoproteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 0/Tumor Markers, Biological; 0/alpha-Fetoproteins; 63503-12-8/Fluorodeoxyglucose F18 |
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