Document Detail

The clinical utility of serum creatinine measurement vs calculated glomerular filtration rate in the assessment of renal function in the premature infant.
MedLine Citation:
PMID:  10148854     Owner:  NLM     Status:  MEDLINE    
The ability to assess the glomerular filtration rate (GFR) without the necessity of collecting urine in premature infants would be of significant clinical benefit. In 1986, the modified Schwartz formula (MSF = 0.33 x length (cm)/plasma creatinine (mg/dL)) was developed. In the MSF, GFR was estimated in premature infants during the first post-natal year. The goal of the present study was to test the applicability of the MSF in premature infants during the neonatal period and to evaluate the clinical use of serum creatinine (Cr) as a predictor of GFR. In 42 premature infants of mean (+/-SD) birthweight 1506.6 (+/-388.8) g, gestational age 31.3 (+/-1.7) wks and post-natal age 14.7 (+/-8.3) d, the correlation between GFR, estimated by endogenous creatinine clearance (ECrC), was compared with the serum Cr and with GFR estimated by the MSF. The correlation coefficient between ECrC and serum Cr was 0.6789 and between estimated GFR derived from ECrC and MSF, 0.4657. In premature infants during the neonatal period, serum Cr has a better correlation with GFR than with MSF. When serum Cr is less than 0.9 mg/dL, the 95% confidence interval suggests that at least 89% of the infants can be expected to have an ECrC within the normal range.
A L Alkalay; S J Farber; P R Ordonez; J J Pomerance
Related Documents :
764974 - Gastrointestinal somatostatin cells in the human fetus.
3179444 - Development of the human coagulation system in the healthy premature infant.
8129324 - Topical anesthesia during infant eye examinations: does it reduce stress?
3114134 - Activities of purine metabolising enzymes in lymphocytes of neonates and young children...
23887114 - Immediate metabolic consequences of intrauterine growth restriction and low birthweight.
14581964 - The safe-t-sleep device: safety and efficacy in maintaining infant sleeping position.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neonatal intensive care : the journal of perinatology-neonatology     Volume:  6     ISSN:  1062-2454     ISO Abbreviation:  Neonatal Intensive Care     Publication Date:    1993 Jul-Aug
Date Detail:
Created Date:  1993-11-24     Completed Date:  1993-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007473     Medline TA:  Neonatal Intensive Care     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-9     Citation Subset:  T    
Division of Neonatology, Cedars-Sinai Medical Center, University of California, Los Angeles, School of Medicine 90048.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Creatinine / analysis*
Glomerular Filtration Rate*
Infant, Newborn
Infant, Premature / blood,  urine*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Developing a medical device package.
Next Document:  Outcome of hospitalization for defendants found incompetent to stand trial.