Document Detail


The clinical utility of radionuclide ventriculography in cardiac transplantation.
MedLine Citation:
PMID:  2266389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess ventricular function in patients who have undergone cardiac transplantation, 247 radionuclide ventriculograms were performed on 94 patients. During the first three days after transplantation, 19% demonstrated left ventricular dysfunction and 41% showed isolated right ventricular dysfunction. In 95 cases, radionuclide ventriculography was performed within 24 hr of myocardial biopsy. A reduction in left ventricular ejection fraction to less than 50% was significantly more common with moderate-severe rejection than with mild rejection. In six instances in which there was discordance between ventriculography and biopsy, radionuclide ventriculography proved particularly useful: three cases showed severe left ventricular dysfunction despite only mild rejection by biopsy, and three cases with ventricular dysfunction from rejection were missed by the initial biopsy. Thus, radionuclide ventriculography can provide functional data in transplant patients that is complementary to myocardial biopsies since biopsy grade is a poor predictor of left ventricular function and biopsy can miss significant rejection.
Authors:
K J Lee; J W Wallis; T R Miller; R M Bolman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  31     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-02-14     Completed Date:  1991-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1933-9     Citation Subset:  IM    
Affiliation:
Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, St. Louis, MO 63110.
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Graft Rejection*
Heart Transplantation / pathology*
Humans
Myocardium / pathology*
Radionuclide Ventriculography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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