Document Detail


The clinical utility of measured kyphosis as a predictor of the presence of vertebral deformities.
MedLine Citation:
PMID:  17143655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Meaured spinal kyphosis, as a predictor of prevalent and incident vertebral deformity, was examined in older women (>70 years) and found to not have sufficient sensitivity or specificity to justify its use as a predictor of present or future vertebral deformity risk. INTRODUCTION: Kyphosis may be attributable to vertebral deformity and was investigated as a clinical tool for predicting the presence and future risk of vertebral deformity. METHODS: Kyphosis was measured in 434 women aged 70 years or older and the kyphosis index (KI) calculated. Prevalent and incident vertebral deformities were assessed by morphometric X-ray absorptiometry (MXA). The predictive value of KI was examined. RESULTS: Severity of kyphosis was categorised by tertile of KI; 65% of anterior thoracic deformities occurred in the 33% of subjects in the highest (most kyphotic) tertile. Using this tertile as a predictor of anterior thoracic deformity, the probability for a positive test rose from 14% for the whole population to 28% and for a negative test the probability fell to 8%. For any spinal deformity the highest tertile of KI increased the probability of a positive test from 34% to 42% and reduced the probability for a negative test to 30%. The incidence of new deformities was 6% over 4 years; a high KI tertile did not increase the probability of any vertebral deformity. CONCLUSIONS: Severe kyphosis does not increase the probability of detection of a prevalent or incident spinal deformity sufficiently to make it a useful method of selecting patients for further evaluation of spinal deformity.
Authors:
R L Prince; A Devine; I M Dick
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-02
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  18     ISSN:  0937-941X     ISO Abbreviation:  Osteoporos Int     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-05-31     Revised Date:  2010-05-10    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  621-7     Citation Subset:  IM    
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia. rlprince@cyllene.uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Aged
Aged, 80 and over
Female
Humans
Incidence
Kyphosis / diagnosis*,  epidemiology,  etiology
Lumbar Vertebrae
Predictive Value of Tests
Prevalence
Prospective Studies
ROC Curve
Severity of Illness Index
Spine / abnormalities*
Thoracic Vertebrae
Western Australia / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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