Document Detail

The clinical use of dopamine in the treatment of shock.
MedLine Citation:
PMID:  1563     Owner:  NLM     Status:  MEDLINE    
Dopamine is a direct-acting catecholamine with a short half-life that has many advantages in treating visceral hypoperfusion states such as shock and refractory heart failure. Unlike other inotropic drugs, dopamine directly dilates the mesenteric, renal, and cerebral vessels and redirects blood flow to essential viscera. This dopaminergic effect is prominent with doses of 100-700 mug/min in adults and is attenuated by phenothiazines and haloperidol. At doses of 700-1400 mug/min, dopamine also has a significant beta-adrenergic, inotropic effect, increasing myocardial contractility. The inotropic effect is equivalent to that of isoproterenol, epinephrine, and norepinephrine, but tachycardia, tachyarrhythmias, and angina may be less frequent with dopamine. In doses greater than 1400 mug/min, dopamine is a vasoconstrictor with pressor effects usually equivalent to that of norepinephrine. Dopamine dilates pupils, does not dilate bronchi, and does not shunt blood from viscera to skeletal muscles as does isoproterenol. Because dopamine increases myocardial contractility, selectively redistributes perfusion to essential viscera and allows a pharmacologic titration of effect, it is a logical first-choice catecholamine for treatment of shock and refractory heart failure.
P R Reid; W L Thompson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Johns Hopkins medical journal     Volume:  137     ISSN:  0021-7263     ISO Abbreviation:  Johns Hopkins Med J     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-03-18     Completed Date:  1976-03-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0072456     Medline TA:  Johns Hopkins Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  276-9     Citation Subset:  IM    
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Adrenergic beta-Agonists / pharmacology
Dopamine / pharmacology,  therapeutic use*
Shock / drug therapy*
Shock, Cardiogenic / drug therapy
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic beta-Agonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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