Document Detail

A clinical trial of topical bleaching treatment with nanoscale tretinoin particles and hydroquinone for hyperpigmented skin lesions.
MedLine Citation:
PMID:  17661936     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although combined use of tretinoin (all-trans-retinoic acid; atRA) and hydroquinone improves various hyperpigmented lesions, the pharmacologic instability of atRA and atRA-induced irritant dermatitis are difficult unsolved problems. OBJECTIVE: The objective was to evaluate the efficacy and adverse effects of a newly formulated gel containing inorganic-coated atRA nanoscale particles (nano-atRA gel). METHODS: Nano-atRA gel was used in our two-phased bleaching protocol: 5% hydroquinone and 7% lactic acid ointment were used along with nano-atRA gel in the bleaching phase (2-8 weeks), and 5% hydroquinone and 7% ascorbic acid ointment were used alone during the healing phase (4-8 weeks). Eighty-four patients with facial hyperpigmented lesions were enrolled in this study, and 77 of them (88 lesions) followed up for more than 10 weeks were analyzed. RESULTS: Hyperpigmentation was improved in 84 of 88 lesions (95.5%) after a mean treatment period of 14.3 weeks and was almost eliminated in 52 lesions (59.1%). Nano-atRA gel caused exfoliation and scaling similar to that seen with conventional atRA gel, whereas the erythema seen in the bleaching phase appeared to be weaker. CONCLUSION: Nano-atRA gel can improve hyperpigmentation to a similar extent as conventional atRA gel. It also induces irritant dermatitis, but with less erythema.
Katsujiro Sato; Daisuke Matsumoto; Fumiko Iizuka; Emiko Aiba-Kojima; Chiaki Machino; Hirotaka Suga; Asami Watanabe-Ono; Keita Inoue; Koichi Gonda; Kotaro Yoshimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  33     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-09-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  937-44     Citation Subset:  IM    
Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan.
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MeSH Terms
Administration, Topical
Aged, 80 and over
Drug Therapy, Combination
Hyperpigmentation / drug therapy*
Middle Aged
Quinidine / administration & dosage,  adverse effects,  analogs & derivatives*
Tretinoin / administration & dosage*,  adverse effects
Reg. No./Substance:
0/Ointments; 1435-55-8/hydroquinidine; 302-79-4/Tretinoin; 56-54-2/Quinidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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