Document Detail

A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy.
MedLine Citation:
PMID:  22726923     Owner:  NLM     Status:  MEDLINE    
Patients with acute myeloid leukemia (AML) receiving induction chemotherapy (IC) were enrolled in a supervised exercise intervention to determine safety, feasibility, and efficacy. Physical fitness measures, quality of life (QOL) and fatigue were assessed using standardized measures at baseline, post-induction, and post first consolidation. Retention was excellent, the intervention was safe, and efficacy estimates suggested benefits in physical fitness and QOL outcomes. Exercise is a safe, promising intervention for improving fitness and QOL in this patient population. These results provide a foundation for a randomized trial to better understand the impact of exercise during IC on clinically important outcomes.
Shabbir M H Alibhai; Sara O'Neill; Karla Fisher-Schlombs; Henriette Breunis; Joseph M Brandwein; Narhari Timilshina; George A Tomlinson; Heidi D Klepin; S Nicole Culos-Reed
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-21
Journal Detail:
Title:  Leukemia research     Volume:  36     ISSN:  1873-5835     ISO Abbreviation:  Leuk. Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-08-17     Completed Date:  2012-11-05     Revised Date:  2013-09-16    
Medline Journal Info:
Nlm Unique ID:  7706787     Medline TA:  Leuk Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1255-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Medicine, University Health Network, Toronto, ON, Canada.
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MeSH Terms
Feasibility Studies
Induction Chemotherapy*
Leukemia, Myeloid, Acute / drug therapy*
Middle Aged
Quality of Life*
Treatment Outcome
Grant Support

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