Document Detail

A clinical trial of oral hyposensitization in systemic allergy to nickel.
MedLine Citation:
PMID:  17026844     Owner:  NLM     Status:  MEDLINE    
Nickel allergy is the most common contact allergy. Some nickel-sensitive patients present systemic (cutaneous and/or digestive) symptoms related to the ingestion of high nickel-content foods, which significantly improve after a specific low nickel-content diet. The etiopathogenetic role of nickel in the genesis of systemic disorders is, furthermore, demonstrated by the relapse of previous contact lesions, appearance of widespread eczema and generalized urticaria-like lesions after oral nickel challenge test. The aim of this study is to investigate the safety and efficacy of a specific oral hyposensitization to nickel in patients with both local contact disorders and systemic symptoms after the ingestion of nickel-containing foods. Inclusion criteria for the recruitment of these patients were (other than a positive patch test) a benefit higher than 80% from a low nickel-content diet and a positive oral challenge with nickel. Based on the previous experiences, our group adopted a therapeutic protocol by using increasing oral doses of nickel sulfate associated to an elimination diet. Results have been excellent: this treatment has been effective in inducing clinical tolerance to nickel-containing foods, with a low incidence of side effects (gastric pyrosis, itching erythema).
D Schiavino; E Nucera; C Alonzi; A Buonomo; E Pollastrini; C Roncallo; T De Pasquale; C Lombardo; G La Torre; V Sabato; V Pecora; G Patriarca
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  19     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2006 Jul-Sep
Date Detail:
Created Date:  2006-10-09     Completed Date:  2006-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  593-600     Citation Subset:  IM    
Department of Allergology, Universita Cattolica del Sacro Cuore, Policlinico -A. Gemelli-, Rome, Italy.
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MeSH Terms
Administration, Oral
Child, Preschool
Desensitization, Immunologic*
Hypersensitivity / therapy*
Middle Aged
Nickel / adverse effects*
Skin Tests
Reg. No./Substance:

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