| A clinical trial and molecular study of photoadaptation in vitiligo. | |
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MedLine Citation:
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PMID: 19067714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Photoadaptation to ultraviolet (UV) B phototherapy is due to both pigmentary and nonpigmentary influences. OBJECTIVES: To measure photoadaptation in vitiliginous skin and to compare it with normal pigmented skin. METHODS: Seventeen patients with Fitzpatrick skin phototypes III-VI with vitiligo received six to nine UVB treatments, two to three times weekly. Minimal erythema dose (MED) testing was done at baseline and after all treatments; the percentage change in MED was analysed as a measure of photoadaptation. The percentage decrease in cyclobutane pyrimidine dimers (CPDs) over 24 h after a single exposure of 1 MED was analysed on vitiliginous and normal skin. RESULTS: The mean +/- SD percentage change in MED from before to after treatments was: treated vitiliginous skin 28.5 +/- 39.9% (P = 0.015), treated normal skin 35.9 +/- 49.9% (P = 0.015), untreated vitiliginous skin 11.9 +/- 22.6% (P =0.070), untreated normal skin 25.1 +/- 41.3% (P = 0.041). Of these patients, two-thirds had a positive percentage change in MED (photoadaptation). The mean amount of CPDs induced per megabase of DNA immediately after exposure was significantly higher in vitiliginous skin. The mean +/- SD percentage decrease in CPDs (rate of repair) in 24 h was 35.7 +/- 26.8% in vitiliginous skin (P = 0.027) and 46.2 +/- 19.5% in normally pigmented skin (P = 0.001); no difference was noted in the repair in vitiliginous skin compared with normal skin (P = 0.4). CONCLUSIONS: Photoadaptation in vitiliginous and normal skin was observed in two-thirds of patients. Vitiliginous skin had significantly more CPDs following UVB exposure; the rate of repair of UVB-induced DNA damage was equivalent to that in normal skin. |
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Authors:
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C L Hexsel; B H Mahmoud; D Mitchell; J Rivard; M Owen; F M Strickland; H W Lim; I Hamzavi |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-05 |
Journal Detail:
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Title: The British journal of dermatology Volume: 160 ISSN: 1365-2133 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-17 Completed Date: 2009-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 534-9 Citation Subset: IM |
Affiliation:
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Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, MI 48202, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00367224 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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genetics,
radiation effects* Adult Aged DNA Damage DNA Repair Female Humans Male Middle Aged Radiation Tolerance / genetics Radiotherapy Dosage Skin / radiation effects Skin Pigmentation Ultraviolet Therapy / methods* Vitiligo / genetics, physiopathology, radiotherapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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