Document Detail

The clinical trial in multidisciplinary research.
MedLine Citation:
PMID:  270465     Owner:  NLM     Status:  MEDLINE    
Dental research has developed along two separate paths. Epidemiological studies can only indicate a cause-disease relationship while laboratory experiments can only be applied to the human situation as a working hypothesis. The final solution can only be arrived at by setting up controlled studies in man, though there are limitations on the possibility of control of some variables in human studies. Experimental studies on the formation of pellicles and plaque are described as examples of the use of clinical trials to bridge the gap between basic research and epidemiological data. The ideal model for dental research would involve the identification of a clinical problem and its subdivision into small biological units which could be studied in the laboratory in order to develop working hypothesis. An in vivo model would then be devised to test the hypotheses and finally they would be applied in a well controlled trial.
P Gjermo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International dental journal     Volume:  27     ISSN:  0020-6539     ISO Abbreviation:  Int Dent J     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374714     Medline TA:  Int Dent J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  D; IM    
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MeSH Terms
Calcium / pharmacology
Chlorhexidine / pharmacology
Dental Caries / prevention & control
Dental Deposits / etiology
Dental Plaque / etiology
Fluorides / therapeutic use
Research Design*
Reg. No./Substance:
0/Fluorides; 55-56-1/Chlorhexidine; 7440-70-2/Calcium

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