Document Detail

A clinical trial of Gingkco Biloba Extract in patients with intermittent claudication.
MedLine Citation:
PMID:  2254678     Owner:  NLM     Status:  MEDLINE    
Thirty-seven patients with stage 2 peripheral vascular disease were randomised to receive a six month course of Gingkco Biloba Extract (Tanakan) or matching placebo. Assessment, by claudication distance, A/B ratio, Doppler ankle pressure response to exercise together with recovery time, and a 10 cm analogue scale (LAS) estimation of maximal pain severity, was performed before treatment, and at 6, 12 and 24 weeks. LAS scores were significantly improved after 24 weeks in patients receiving EgB, but not placebo. Claudication distance was significantly increased by Egb. Although claudication distance also increased in the placebo group, this was not significant. A/B ratio and Doppler ankle responses to exercise did not show any significant change in either group at any time interval, nor did the post exercise recovery time. Gingkco Biloba Extract is a safe and effective method of improving walking distance and reducing pain severity in patients with intermittent claudication, although Doppler studies have failed to suggest any gross improvement in the perfusion of the ischaemic leg.
G J Thomson; R K Vohra; M H Carr; M G Walker
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  9     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:    1990 Apr-Jun
Date Detail:
Created Date:  1991-01-24     Completed Date:  1991-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  IM    
Department of Vascular Surgery, Manchester Royal Infirmary, G.B.
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MeSH Terms
Double-Blind Method
Ginkgo biloba
Intermittent Claudication / drug therapy*,  ultrasonography
Plant Extracts / therapeutic use*
Time Factors
Reg. No./Substance:
0/Ginkgo biloba extract 761; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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