Document Detail


A clinical study on the effects and mechanism of xuebijing injection in severe pneumonia patients.
MedLine Citation:
PMID:  21563507     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To observe the effects of Xuebijing Injection in patients with severe pneumonia, and to explore the mechanism.
METHODS: Eighty cases of severe pneumonia are randomly assigned to the Xuebijing treatment (forty cases) and the control group (forty cases), with the same routine therapy provided in both groups. Clinical effective rates, inflammatory factors and organ function were observed in both groups.
RESULTS: The effective rate was higher in Xuebijing group than that of the control group (80.0% vs. 67.5%, P < 0.05). As compared with the control group, the LDH, alpha1-AG, alpha1-AT levels and the peak body temperature decreased markedly with the Xuebijing treatment going, and the secretion of TNF-alpha, IL-6, IL-8 was suppressed in Xuebijing group; but no significant difference was found in leptin level.
CONCLUSION: Xuebijing Injection may show a protective effect in patients with severe pneumonia. The mechanism is possibly with the decreased secretion of TNF-alpha, IL-6, and IL-8.
Authors:
Fei Qi; Zhi-Xin Liang; Dan-Yang She; Guang-Tao Yan; Liang-An Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine     Volume:  31     ISSN:  0255-2922     ISO Abbreviation:  J Tradit Chin Med     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-05-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211546     Medline TA:  J Tradit Chin Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  46-9     Citation Subset:  IM    
Affiliation:
Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing 100853, China.
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