Document Detail

The clinical study of POEMS syndrome in China.
MedLine Citation:
PMID:  20424579     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: POEMS syndrome is a unique clinical entity. It was described by the presence of several typical characteristics as paraproteinemia, polyneuropathy, organomegaly, endocrinopathy, and skin changes. Few people reported characteristics of Chinese POEMS patients. PATIENTS AND METHODS: Retrospective evaluation of Chinese patients with POEMS syndrome was carried out to reveal clinical features and compare with foreign series reported previously. In addition to typical characteristics, Chinese patients often were presented with extravascular volume overload (84%), papilledema (44%), bone lesions (41%), raynaud phenomenon (31%) and Clubbing (22%). RESULTS: Clinical laboratory tests found most patients had increased erythrosedimentation rate, hyperlipidemia, liver disorder and renal involvement. 70% patients had hypothyroidism, including overt hypothyroidism (6 patients) and subclinical hypothyroidism (13 patients). High prevalence of positive antimitochondrial antibody (ANA) and positive antineutrophil cytoplasmic antibody (ANCA) was the more common phenomenon. Chinese patients with bone damage in the incidence are lower than in the West and Japanese reports. CONCLUSIONS: In summary, our study demonstrate the POEMS syndrome diagnostic criteria proposed by Dispenzieri et al is also more high applicability in the Chinese population.At the time of diagnosis, we should not pay attention on the typical characteristics of the disease, but also on the changes in thyroid, liver, kidney function and lipid metabolism.
Bin Zhang; XingWang Song; Bin Liang; QingHua Hou; ShuXiang Pu; Jian Rui Ying; Cong Gao
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  31     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  229-37     Citation Subset:  IM    
Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience and Department of Neurology, The Second Affiliated Hospital of GuangZhou Medical Universit, China.
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MeSH Terms
Aged, 80 and over
Antibodies, Antineutrophil Cytoplasmic / blood
Autoantibodies / blood
Blood Sedimentation
China / epidemiology
Hyperlipidemias / blood,  epidemiology
Hypothyroidism / blood,  epidemiology
Kidney / physiopathology
Liver / physiopathology
Middle Aged
Mitochondria / immunology
POEMS Syndrome / blood,  diagnosis*,  epidemiology,  physiopathology*
Papilledema / epidemiology,  physiopathology
Retrospective Studies
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Autoantibodies

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