| The clinical spectrum of thrombotic thrombocytopenic purpura. | |
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MedLine Citation:
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PMID: 16388418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The clinical syndrome of fever, neurologic abnormalities, renal impairment with laboratory findings of thrombocytopenic and microangiopathic hemolytic anemia is seen in thrombotic thrombocytopenic purpura (TTP) and a variety of disorders associated with thrombotic microangiopathy (TMA). With improved understanding of the pathogenesis of the perturbed metabolic pathway of von Willebrand factor in TTP, the classic Moschcowitz syndrome, now more accurately referred to as idiopathic TTP, can be distinguished from other TMAs. The distinguishing features are useful not only in providing an accurate diagnosis but also help to determine the best therapeutic strategy. |
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Authors:
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Hau C Kwaan; Lisa N Boggio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Seminars in thrombosis and hemostasis Volume: 31 ISSN: 0094-6176 ISO Abbreviation: Semin. Thromb. Hemost. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-01-02 Completed Date: 2006-06-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0431155 Medline TA: Semin Thromb Hemost Country: United States |
Other Details:
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Languages: eng Pagination: 673-80 Citation Subset: IM |
Affiliation:
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Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. h-kwaan@northwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Hemolytic
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diagnosis,
pathology,
physiopathology Diagnosis, Differential Fever / diagnosis, pathology, physiopathology Humans Kidney Diseases / diagnosis, pathology, physiopathology Microcirculation / pathology, physiopathology Nervous System Diseases / diagnosis, pathology, physiopathology Purpura, Thrombotic Thrombocytopenic / diagnosis, pathology*, physiopathology*, therapy Syndrome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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