| Is the clinical spectrum and prognosis of native valve infective endocarditis in non-addicts changing? | |
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MedLine Citation:
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PMID: 8881865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One hundred and ninety-four episodes of endocarditis on native valves in non-addict patients were diagnosed from 1975 to 1992 and were divided into groups A (78 patients, 1975-1983) and B (116 patients 1984-1992). Both groups had the same gender distribution, similar valvular involvement and microbiological characteristics. In group B patients, median age was older (46 vs 54 years, P = 0.0002), the number of patients without previous heart disease was higher (46% vs 22%, P = 0.02) and the median time of symptoms before diagnosis was shorter (30 vs 50 days, P = 0.038). Both groups had similar incidence of heart failure (32% vs 36%), surgical treatment (30% vs 33%) and embolic episodes (26% vs 34%). Surgical mortality decreased from 43% to 18% (P = 0.03). Overall mortality decreased non-significantly from 19% in group A to 12% in group B. Predictors of death in group A were heart failure (odds ratio 9.6, 95% confidence interval 3-36) and surgical treatment (odds ratio 5, 95% confidence interval 1.3-19). Predictors of death in group B were age (odds ratio 4.98, 95% confidence interval 1.4-19), female sex (odds ratio 5.3, 95% confidence interval 1.3-20), staphylococcal infection (odds ratio 4.9, 95% confidence interval 1.1-22) and heart failure (odds ratio 5.2, 95% confidence interval 1.3-20). Although in recent years infective endocarditis occurs in older patients and is more common in patients with previously unknown heart disease a substantial change in major clinical and prognostic variables is not apparent in our population. Overall in-hospital mortality has decreased from 19% to 12% mainly due to better surgical results. |
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Authors:
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M P Tornos; M Olona; G Permanyer-Miralda; B Almirante; A Evangelista; J Soler-Soler |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European heart journal Volume: 16 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-12-17 Completed Date: 1996-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1686-91 Citation Subset: IM |
Affiliation:
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Servicio de Cardiología, Hospital General Universitario Vall d'Hebron, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Aged, 80 and over Cardiac Output, Low / etiology Child Endocarditis, Bacterial / epidemiology, physiopathology*, surgery Female Hospital Mortality Humans Male Middle Aged Prognosis Retrospective Studies Sex Factors Substance-Related Disorders Survival Analysis |
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