Document Detail

The clinical spectrum of postpartum thyroid disease.
MedLine Citation:
PMID:  8758046     Owner:  NLM     Status:  MEDLINE    
The clinical and biochemical features of postpartum thyroid disease were analysed in 152 antithyroid peroxidase antibody-positive (anti-TPO+ve) women and compared with 239 anti-TPO-ve age-matched control postpartum women. All were assessed monthly for up to 12 months postpartum. Seventy three anti-TPO+ve women developed postpartum thyroiditis (PPT): 19.2% hyperthyroid alone, 49.3% hypothyroid alone, and 31.5% characterized by hyper- followed by hypothyroidism. None of the antibody-negative women developed any thyroid dysfunction. A significant increase in many of eleven symptoms of hypothyroidism and some of eight symptoms of hyperthyroidism compared to control women was observed in all anti-TPO+ve women, independent of thyroid status. This was particularly seen in women who later developed PPT when they were euthyroid, but was also observed in euthyroid anti-TPO+ve women who showed no decline of thyroid function during the postpartum period. Although PPT is usually transient, this condition, and the euthyroid antibody-positive state, may be associated with significant symptomatology, including an increased incidence of minor to moderate depression. Early recognition of this syndrome by antenatal screening of thyroid antibodies may contribute to improved management of women during the postpartum period.
J H Lazarus; R Hall; S Othman; A B Parkes; C J Richards; B McCulloch; B Harris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  QJM : monthly journal of the Association of Physicians     Volume:  89     ISSN:  1460-2725     ISO Abbreviation:  QJM     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-10-25     Completed Date:  1996-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9438285     Medline TA:  QJM     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  429-35     Citation Subset:  IM    
Department of Medicine, University of Wales College of Medicine, Cardiff, UK.
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MeSH Terms
Autoantibodies / blood*
Autoimmune Diseases / immunology*
Follow-Up Studies
Hyperthyroidism / immunology
Hypothyroidism / immunology
Iodide Peroxidase / immunology*
Puerperal Disorders / immunology*
Thyroid Diseases / complications,  immunology*
Reg. No./Substance:
0/Autoantibodies; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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