Document Detail


The clinical significance of tissue polypeptide antigen (TPA) in the urine of bladder cancer patients.
MedLine Citation:
PMID:  7317745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 2-stage study has been carried out to evaluate the usefulness of urinary tissue polypeptide antigen (TPA) levels in patients with bladder cancer as an adjunct to the routine procedures for detection of bladder tumours. Two-hour urine samples were collected from 83 bladder cancer patients and normal individuals for the first part of the study, 24-h samples from 54 patients and normal individuals for the second part. Urinary TPA was determined using radioimmunoassay. In 2-h samples there was no significant difference in the amounts of TPA/l in any of the groups. In contrast, the TPA results of 24-h urine samples (n = 54) were markedly different from 2-h samples and the former correlated very well with the presence or absence of bladder cancer. A reason for this difference may be circadian rhythm effects.
Authors:
S Kumar; C B Costello; R W Glashan; B Björklund
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of urology     Volume:  53     ISSN:  0007-1331     ISO Abbreviation:  Br J Urol     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15740090R     Medline TA:  Br J Urol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  578-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antigens, Neoplasm / urine*
Humans
Peptides / urine*
Radioimmunoassay
Tissue Polypeptide Antigen
Urinary Bladder Neoplasms / immunology*,  urine
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Peptides; 0/Tissue Polypeptide Antigen

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