| The clinical significance of "squamous intraepithelial lesion of indeterminate grade" as a distinct cytologic category. | |
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MedLine Citation:
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PMID: 22523214 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The histologic and/or cytologic follow-up of 127 cases of cervical lesions termed "squamous intraepithelial lesion of indeterminate grade" (SIL) on Papanicolaou (Pap) smears by the 2001 Bethesda System was compared with 150 control cases of low-grade SIL (LSIL), high-grade SIL (HSIL), and atypical squamous cells, cannot exclude HSIL (ASC-H). A follow-up diagnosis of cervical intraepithelial neoplasia (CIN) 2 or higher was identified in 22.8% of SIL cases, which was 2.6 times higher than LSIL, 3 times lower than HSIL, and 1.5 times lower than ASC-H. A follow-up diagnosis of CIN 1 was identified in 31.5% of SIL cases, which was 2 times lower than the LSIL group, 1.5 times higher than the ASC-H cases, and 1.8 times higher than the HSIL group. We found that 22.0% of cases diagnosed as SIL were followed up by Pap smears rather than colposcopy and biopsy, compared with about 1% of LSIL and HSIL cases. Because SIL cases have a significant risk of harboring CIN 2 or greater, we recommend follow-up by colposcopy and biopsy. |
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Authors:
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Dorothy Wong; Crystal Teschendorf; Grace Y Lin; Farnaz Hasteh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 137 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 753-60 Citation Subset: AIM; IM |
Affiliation:
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Dept of Pathology, University of California San Diego Medical Center, 200 W Arbor Dr, MC 8720, San Diego, CA 92103-8720. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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