Document Detail


The clinical significance of the lack of arterial or venous thrombosis in patients with congenital prothrombin or FX deficiency.
MedLine Citation:
PMID:  19412729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several reports have dealt with the occurrence of both arterial and venous thrombosis in patients with haemophilia A, haemophilia B, and von Willebrand disease. Similar thrombotic events have been occasionally reported also in rare congenital coagulation disorders, particularly in fibrinogen or FVII deficiencies. On the contrary no sure venous or arterial thrombotic event has ever been reported in congenital prothrombin or Factor X deficiency. The significance of this observation is discussed. This discrepancy cannot be explained on the basis of the rarity of the two conditions, since in similarly rare congenital bleeding disorders such as FV or FXIII deficiency a few patients with thrombosis have been described. It appears that only these two defects are able to allow a sure protection from thrombosis. These observations may indirectly support the rationale for the use of direct thrombin or Factor X inhibitors in the prophylaxis and/or therapy of thrombotic manifestations.
Authors:
Antonio Girolami; Nicole Candeo; Silvia Vettore; Anna Maria Lombardi; Bruno Girolami
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  29     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  299-302     Citation Subset:  IM    
Affiliation:
University of Padua, Padua, Italy. antonio.girolami@unipd.it
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MeSH Terms
Descriptor/Qualifier:
Arteriosclerosis* / blood,  diagnosis,  genetics
Blood Coagulation Disorders, Inherited / blood,  diagnosis,  genetics
Factor X Deficiency / blood,  diagnosis,  genetics*
Humans
Hypoprothrombinemias* / blood,  diagnosis,  genetics
Venous Thrombosis* / blood,  diagnosis,  genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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