| The clinical significance of the lack of arterial or venous thrombosis in patients with congenital prothrombin or FX deficiency. | |
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MedLine Citation:
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PMID: 19412729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several reports have dealt with the occurrence of both arterial and venous thrombosis in patients with haemophilia A, haemophilia B, and von Willebrand disease. Similar thrombotic events have been occasionally reported also in rare congenital coagulation disorders, particularly in fibrinogen or FVII deficiencies. On the contrary no sure venous or arterial thrombotic event has ever been reported in congenital prothrombin or Factor X deficiency. The significance of this observation is discussed. This discrepancy cannot be explained on the basis of the rarity of the two conditions, since in similarly rare congenital bleeding disorders such as FV or FXIII deficiency a few patients with thrombosis have been described. It appears that only these two defects are able to allow a sure protection from thrombosis. These observations may indirectly support the rationale for the use of direct thrombin or Factor X inhibitors in the prophylaxis and/or therapy of thrombotic manifestations. |
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Authors:
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Antonio Girolami; Nicole Candeo; Silvia Vettore; Anna Maria Lombardi; Bruno Girolami |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of thrombosis and thrombolysis Volume: 29 ISSN: 1573-742X ISO Abbreviation: J. Thromb. Thrombolysis Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-12 Completed Date: 2010-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502018 Medline TA: J Thromb Thrombolysis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 299-302 Citation Subset: IM |
Affiliation:
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University of Padua, Padua, Italy. antonio.girolami@unipd.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteriosclerosis*
/
blood,
diagnosis,
genetics Blood Coagulation Disorders, Inherited / blood, diagnosis, genetics Factor X Deficiency / blood, diagnosis, genetics* Humans Hypoprothrombinemias* / blood, diagnosis, genetics Venous Thrombosis* / blood, diagnosis, genetics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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