Document Detail


The clinical significance of the gastro-oral pathway of intestinal bacteria after head and neck cancer surgery.
MedLine Citation:
PMID:  3442946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intestinal aerobic gram-negative bacilli (IAGB) are considered to be important in the pathogenesis of wound infection following major head and neck surgery. These micro-organisms have been shown to originate endogenously from the stomach, in spite of broad spectrum chemoprophylaxis. We have attempted to interrupt this gastro-oral pathway by instilling an antiseptic (40% ethanol) into the stomach after surgery. We studied 16 patients who were randomly allocated to an 'alcohol' or control group. Alcohol was administered to 8 patients regularly via the nasogastric tube until the 5th postoperative day. The mouth, tracheostomy site and gastric aspirates were sampled on the 1st, 5th, and 10th days after surgery. No patients had IAGB grown from the mouth before surgery, but after surgery coliforms were prolific in all sites in both patient groups, and the administration of alcohol did not have any noticeable affect. However, even though coliforms were ubiquitous during the recovery period, wound complications were few, and their importance in the pathogenesis of wound sepsis is reconsidered.
Authors:
A C Swift; C A Bartzokas; J E Corkill
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical otolaryngology and allied sciences     Volume:  12     ISSN:  0307-7772     ISO Abbreviation:  Clin Otolaryngol Allied Sci     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-05-03     Completed Date:  1988-05-03     Revised Date:  2005-05-02    
Medline Journal Info:
Nlm Unique ID:  7701793     Medline TA:  Clin Otolaryngol Allied Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  455-9     Citation Subset:  IM    
Affiliation:
University Department of Otorhinolaryngology, Royal Liverpool Hospital.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Ethanol / administration & dosage,  therapeutic use*
Female
Gram-Negative Aerobic Bacteria / drug effects,  isolation & purification*
Head and Neck Neoplasms / surgery*
Humans
Intestines / microbiology*
Intubation, Gastrointestinal
Male
Middle Aged
Mouth / microbiology
Random Allocation
Stomach / microbiology
Surgical Wound Infection / microbiology,  prevention & control
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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