| The clinical significance of eosinophils in the amniotic fluid in preterm labor. | |
| | |
MedLine Citation:
|
PMID: 19900034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: White blood cells are not traditionally considered to be normally present in amniotic fluid. This study was conducted after the observation that a patient with preterm labor and intact membranes had eosinophils as a predominant cell in the amniotic fluid, and had an episode of asthma during the index pregnancy. The goal of this study was to determine whether women presenting with preterm labor with eosinophils in the amniotic fluid had a different outcome than those without eosinophils as the predominant white blood cell in the amniotic cavity. METHODS: This retrospective case-control study included women who presented with preterm labor and intact membranes between 24 and 34 weeks of gestation. Patients underwent an amniocentesis shortly after admission for the assessment of the microbiologic status of the amniotic cavity and/or fetal lung maturity. Amniotic fluid was cultured for aerobic and anaerobic bacteria as well as genital mycoplasmas. Cytologic studies included amniotic fluid white blood cell count and differential, which was performed on cytocentrifuged specimens. Patients with microbial invasion of the amniotic cavity and/or an amniotic fluid white blood cell count >20 cells/mm(3) were excluded from the study. Cases were defined as women in whom the differential contained >20% of eosinophils. Controls were selected among women with an amniotic fluid eosinophil count <or=20% and matched for gestational age at amniocentesis. The analysis was conducted with non-parametric statistics. RESULTS: The study population consisted of 10 cases and 50 controls. Gestational age and cervical dilatation at admission were similar in both groups. Cases had a lower gestational age at delivery than controls [34.6 weeks, inter-quartile range (IQR) 32-37.3 weeks vs. 38.0 weeks, IQR 35-40 weeks, respectively; p = 0.018]. The prevalence of preterm delivery <or=35 weeks was higher among patients who had >20% eosinophils than in the control group [50% (5/10) vs. 18% (9/50), respectively; p = 0.029]. Similar results were observed for delivery at <37 weeks [cases: 70% (7/10) vs. controls: 36% (18/50); p = 0.046]. CONCLUSIONS: Women with preterm labor and intact membranes who have a large proportion of eosinophils in the amniotic fluid are at an increased risk for spontaneous preterm delivery. These patients may have had an episode of preterm labor related to a type I hypersensitivity reaction. |
| | |
Authors:
|
Roberto Romero; Juan Pedro Kusanovic; Ricardo Gomez; Ronald Lamont; Egle Bytautiene; Robert E Garfield; Pooja Mittal; Sonia S Hassan; Lami Yeo |
Related Documents
:
|
15036704 - Amniotic vascular endothelial growth factor (vegf) and nitric oxide (no) in women with ... 15791664 - Prenatal diagnosis of megacystis-microcolon-intestinal hypoperistalsis syndrome: contri... 2083574 - 11 beta-hydroxyandrostenedione in human amniotic fluid. 15756664 - Correlation between fetal gastric size and amniotic fluid volume. 3541624 - Advanced ultrasonic placental maturation in twin pregnancies. 2807034 - Reduction of hydroxyproline content in the vessels of the human umbilical cord in prema... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
|
Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 23 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-12 Completed Date: 2010-06-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
|
Languages: eng Pagination: 320-9 Citation Subset: IM |
Affiliation:
|
Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland, USA. prbchiefstaff@med.wayne.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amniocentesis Amniotic Fluid / cytology* Asthma / pathology Case-Control Studies Eosinophils / pathology* Female Gestational Age Humans Obstetric Labor, Premature / pathology* Pregnancy Pregnancy Complications / pathology Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Could alterations in maternal plasma visfatin concentration participate in the phenotype definition ...
Next Document: Changes in amniotic fluid concentration of thrombin-antithrombin III complexes in patients with pret...