Document Detail


The clinical significance of autoantibodies to the proliferating cell nuclear antigen (PCNA).
MedLine Citation:
PMID:  22381917     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Autoantibodies targeting proliferating cell nuclear antigen (PCNA) were first described over 30years ago and are historically most commonly associated with systemic lupus erythematosus (SLE). The primary antigenic target is a 34kDa protein that is part of the DNA polymerase delta multi-protein complex. A number of diagnostic platforms have incorporated PCNA into their diagnostic assays and algorithms. However, little is known about the clinical utility of autoantibodies to PCNA, especially with novel detection systems. This review will focus on the history of the discovery of the PCNA autoantigen and the current status of the diagnostic significance of anti-PCNA and suggest future studies that are required to strengthen our understanding of their clinical utility.
Authors:
M Mahler; K Miyachi; C Peebles; M J Fritzler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-22
Journal Detail:
Title:  Autoimmunity reviews     Volume:  -     ISSN:  1873-0183     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-3-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
INOVA Diagnostics, INC. San Diego, CA, USA.
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