Document Detail

The clinical significance of QTc dispersion measurement for risk of syncope in patients with aortic stenosis.
MedLine Citation:
PMID:  12053497     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: (1) To evaluate the clinical usefulness of QTc dispersion determination in aortic stenosis and (2) to compare the effects of QTc dispersion on the occurrence risk of syncope in aortic stenosis. BACKGROUND: QT interval dispersion has long been known to be a marker of dispersion of ventricular repolarization and, hence, electrical instability. Additionally, it has been shown that these patients have a propensity to ventricular tachyarrhythmic syncope. METHODS: The study included 86 patients with aortic stenosis who underwent left-heart catheterization and coronary angiography during investigation of syncope, as well as 30 control subjects. The patients were characterized with regards to the presence or absence of a history of syncope and the severity of aortic stenosis (the degree of peak transvalvular gradient). In addition, QT dispersion measurements were corrected for heart rate according to Bazett's formula and both were measured. RESULTS: QTc dispersion was greater in patients with aortic stenosis than in the control subjects (60 +/- 13 msec vs 38 +/- 12 msec, P < 0.001). Similarly, QTc dispersion was greater in the patients with a history of syncope than in the patients with no history of syncope (68 +/- 12 msec vs 53 +/- 10 msec, P < 0.001). In addition, QTc dispersion values were greater in the patients with a high transvalvular gradient than in the patients with a low transvalvular gradient (65 +/- 12 msec vs 50 +/- 9 msec, P < 0.001). Multivariate logistic regression analysis showed that only an increased QTc dispersion had significant value for the risk of syncope in aortic stenosis. CONCLUSIONS: An increased QTc dispersion increases the occurrence risk for syncope in aortic stenosis. These results suggest that high values of QTc dispersion are a sensitive noninvasive marker for determining the risk for syncope in aortic stenosis.
F Koşar; I Tandoğan; I Hisar; Y Aytan; M Ileri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  14     ISSN:  0896-4327     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2002-06-10     Completed Date:  2002-07-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-32     Citation Subset:  IM    
Inönü University, School of Medicine, Turgut Ozal Medical Center, Department of Cardiology, Malatya, Turkey.
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MeSH Terms
Aged, 80 and over
Aortic Valve Stenosis / complications*,  physiopathology*
Coronary Circulation / physiology
Long QT Syndrome / complications*,  physiopathology*
Middle Aged
Risk Factors
Syncope / etiology*,  physiopathology*

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